The aim of this study was to develop suitable microemulsion gel systems for transdermal delivery that could assist dissolution enhancement of poorly water soluble celecoxib and thus improve its skin permeability. Long term oral administration of celecoxib causes serious gastrointestinal adverse effects, which makes it a good candidate for transdermal formulations, yet its low water solubility (...

A microemulsion system containing Thai mango seed kernel extract (MSKE, cultivar "Fahlun") was developed and characterised for the purpose of topical skin delivery. The MSKE-loaded microemulsions were prepared by using the spontaneous emulsification method. Isopropyl myristate (IPM) was selected as the oil phase. A polyoxyethylene sorbitan monooleate and sorbitan monododecanoate (1:1, w/w) syst...

The effect of a TEI enhancer mixed system consisting of triethanolamine (T), ethanol (E) and isopropyl myristate (IPM) on the skin permeation of acidic, basic and neutral drugs were evaluated in vitro using excised hairless rat skin. The binary enhancer system consisting of IPM and ethanol (El) produced marked improvement on the penetration of all the drugs tested. When T was added to the EI sy...

Grape-based brandies are one of the most popular alcoholic beverages in world. The one, Cognac, comes from Charentes region Southwest France, and it is mostly produced grape variety ‘Ugni Blanc’. However, wines destined for elaboration wine spirits also come different white varieties; ‘Colombard’, ‘Folle Blanche’, ‘Montils’, ‘Semillon’. In this study, possibility using red varieties ‘Cabernet S...

Growth factors (GFs) are indispensable in regenerative medicine because of their high effectiveness. However, as GFs degenerate easily, the development a suitable carrier with improved stability for is necessary. In this study, we developed gel-in-oil (G/O) emulsion technology transdermal delivery growth factors. Nanogel particles prepared heparin-immobilized gelatin that can bind were disperse...

A biocompatible microemulsion system comprising of isopropyl myristate (IPM) as oil, tween 80 as a non-ionic surfactant and isobuthanol as co-surfactant was studied experimentally at 298.15 K. The pseudo-ternary phase diagram for the microemulsion system has been delineated at different surfactant to co-surfactant mass ratio of 1:1, 2.4:1 and 4:1. Some physico-chemical properties such as densit...

Acyclovir, a BCS class III drug, has high ability to fight the herpes virus but low permeability and is poorly soluble in water. In order obtain expected effect of viral infection on skin, penetration active ingredients becomes critical factor for topical treatment achieve desired concentration. This study was see adding isopropyl myristate propylene glycol as enhancers that help diffuse drug t...