conclusions the results of this study supported the potential protective effects of zncl2 on rat kidney tissues against cdcl2 toxicity. results in contrast to the animals that received zncl2, cdcl2 induced a dose-dependent elevation in bun, creatinine, and mda in those without zncl2 pretreatment. zinc chloride had significantly decreased all biochemical parameters and protected kidney cells aga...

objective: diabetes is an important risk factor for cardiovascular events. the great percent of morbidity in patients with diabetes is due to endothelial dysfunction. the present study investigated the effects of hydroalcholic extract of nigella sativa (n. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (stz)-induced diabetic rat. materials and methods: rats ...

Abstract Background and Aims The most common effect of renal disease in the world is diabetic nephropathy (DN). Dipeptidyl peptidase–IV (DPP-IV) enzyme abundant present kidney, which increased nephropathy. A novel approach to treat type 2 diabetes mellitus (T2DM) along with DN, based on incretin hormones: glucagon-like peptide-1 (GLP-1) regulated by DPP-IV. We hypothesized that DPP-IV inhibitor...

conclusions according to the results of this study, vitamin e probably improves the harmful effects of formaldehyde on rat kidney tissue. results comparison of the control and formaldehyde groups with the vitamin e group revealed that there were significant differences in lumen size and nuclear color of proximal tubules in rats treated by vitamin e (p < 0.05). cell degeneration, lumen size, num...

Objective: To develop Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) method for the estimation of adenosine A 1 receptor mRNA levels in rat kidney. Material and Methods: Total cellular RNA was isolated from whole rat kidney by small-scale total RNA preparation protocol and it was reverse transcribed into cDNA. The cDNA was subjected to PCR amplification using gen specific primers. The...

introduction: in the current study, protective effect of natural honey applied during ischemia/reperfusion (i/r) was studied on infarct size in ischemic heartheart. methods: ischemic hearthearts (n=8 per group) were mounted on a langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. in control group, the hearts were perfused by a m...

introduction: in the present study, potential differences between the effects of l-carnitine (lc) and acetyl-lcarnitine (alc) on ischemia/reperfusion (i/r)-induced myocardial infarction size were investigated. methods: male wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. hearts of the animals were removed and quickly mounted on a langendorff app...

imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...

Isolated kidneys taken from normotensive Wistar-Kyoto rats were cross-perfused extracorporeally by normotensive strain-matched donor rats. The extracorporeal perfusion circuit was arranged so that the perfusion pressure to the normotensive recipient kidney could be varied from 90 to 200 mm Hg without any change in total flow through this circuit. This setup avoided hemodynamic or mechanical int...