The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible-light photoredox catalysis. A wide range of readily available mono-, di-, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a ...

A general, atom-economical method for the synthesis of phosphaalkenes is reported via the net coupling of primary alkyl or aryl phosphines with aryl or alkyl isocyanides at zirconium. The phosphorus-containing ligand can be liberated as the phosphaformamide from zirconium by reaction with an organic electrophile.

The reaction between a transition metal carbonyl compound, L(n)MCO, and Li[Me(3)SiNR] yields the corresponding isocyanide derivative, L(n)MCNR, thereby providing a new route to transition metal isocyanide compounds that does not require the use of free isocyanides as reagents.

An efficient route to 5H-benzo[d]imidazo[5,1-b][1,3]thiazines has been developed using the copper(i)-catalyzed tandem reaction of o-alkynylphenyl isothiocyanates with isocyanides in THF with Cs2CO3 as base. The present tandem process allows the assembly of a variety of 5H-benzo[d]imidazo[5,1-b][1,3]thiazines in good to excellent yields.

An efficient combination between the Passerini three-component reaction and aldol condensation has been developed for the synthesis of bicyclic isocoumarins with different substituted patterns via solvent-dependent domino pathways. These two operationally friendly methods simultaneously install C-O and C-C bonds in a one-pot manner, allowing the utilization of low-cost and readily accessible 2-...

The first amido-distannyne, L(†)SnSnL(†) (L(†) = -N(Ar(†))(SiPr(i)3), Ar(†) = C6H2{C(H)Ph2}2Pr(i)-2,6,4), has been prepared and shown to possess a very long Sn-Sn single bond; the compound activates dihydrogen under ambient conditions to give L(†)Sn(μ-H)2SnL(†), and reacts with Bu(t)NC to give a stable adduct complex, L(†)(Bu(t)NC)SnSn(CNBu(t))L(†).

Reactions of laser-ablated U atoms with (CN)2 produce UNC, U(NC)2, and U(NC)4 as the major products, identified from their Ar matrix infrared spectra and precursors partially and fully substituted with (13)C and (15)N. Mixed isotopic multiplets substantiate product stoichiometries. Band positions and quantum chemical calculations verify the isocyanide bonding.

Nano-copper(0) stabilized on alumina prepared from Cu-Al hydrotalcite has been reported for completely regioselective synthesis of 2,4-disubstituted pyrroles from unactivated terminal aromatic/aliphatic alkynes and isocyanides. The reaction is operationally simple, involves ligand-free inexpensive nano-copper, and affords products in high yields.