Since the disaster in Bhopal, India, people exposed to methyl isocyanate (MIC) have complained of various disorders including neuromuscular dysfunction. In an attempt to get information about such dysfunction we have previously shown that MIC can affect muscle cells in culture. The present communication reports investigations into the effect of MIC on brain cells in culture. MIC was toxic to br...

Isocyanates are a leading cause of work-related asthma and workers in the auto-collision repair industry are at high risk for isocyanate exposures, particularly by the dermal route (Bello et al, 2007a and SHARP 2005). This project aims to extend and validate a rapid colorimetric surface wipe method, SWYPE™, for measuring isocyanate surface contamination in the workplace (Liu et al 2000 and 2005...

a simple, highly sensitive, accurate and selective method for determination of trace amounts of co(ii) in water samples is presented. isocyanate treated graphite oxides (igos) solid phase extraction adsorbent was synthesized by covalently isocyanate onto the surfaces of graphite oxides. the stability of a chemically (igos) especially in concentrated hydrochloric acid which was then used as a re...

A simple, highly sensitive, accurate and selective method for determination of trace amounts of Co(II) in water samples is presented. Isocyanate treated graphite oxides (iGOs) solid phase extraction adsorbent was synthesized by covalently isocyanate onto the surfaces of graphite oxides. The stability of a chemically (iGOs) especially in concentrated hydrochloric acid which was then used as a re...

A simple, highly sensitive, accurate and selective method for determination of trace amounts of Co(II) in water samples is presented. Isocyanate treated graphite oxides (iGOs) solid phase extraction adsorbent was synthesized by covalently isocyanate onto the surfaces of graphite oxides. The stability of a chemically (iGOs) especially in concentrated hydrochloric acid which was then used as a re...

was chemically bonded to poly-L-lysine and to bovine serum albumin (BSA) and showed a paramagnetic resonance spectrum that was sensitive to known structural changes in these molecules, such as those produced by changes in pH.2 This nitroxide-isocyanate is unfortunately not an ideal spin-labeling reagent since it is unstable and thus difficult to purify, and moreover the isocyanate group is rapi...

AIMS Because logistical and financial obstacles impede using large prospective cohort studies, surveillance decisions in occupational settings must often be made without evidence of relative benefits and costs. Using the example of isocyanate induced asthma, the most commonly reported immune mediated occupational asthma, the authors developed a model based approach to evaluate the costs and ben...

Fotemustine is a clinically used DNA-alkylating 2-chloro-ethyl-substituted N-nitrosourea, which sometimes shows signs of haematotoxicity and reversible liver and renal toxicity as toxic side-effects. Mechanistic data on these side-effects are scarce and incomplete. In this study, firstly the cytotoxicity of fotemustine in freshly isolated rat hepatocytes was investigated and secondly the metabo...

Versatile functionalization of metal clusters is a key step in understanding the reactivity of protective monolayers. We here demonstrate that reaction of the outermost amino groups on (S)-/(R)-penicillamine-protected gold clusters with ethyl isocyanate readily modifies the chiral surface structure through carbamoylation. Interestingly, the clusters are electrophoretically separated by the size...