نتایج جستجو برای: ischemiareperfusion injury pyramidal neurons

تعداد نتایج: 484663  

Journal: :iranian biomedical journal 0
فریده بهرامی farideh bahrami مهیار جان احمدی mahyar janahmadi

introduction: antibiotic supplements are regularly used in neuronal culture media to control contamination however, they can interfere with the neuronal excitability and affect electrophysiological properties. therefore, in this study, the effect of penicillin/streptomycin supplements on the spontaneous electrophysiological activity of hippocampal pyramidal neurons was examined. methods: electr...

2014
Steven K White Georg M Frohlich Daniel Sado Viviana Maestrini Marianna Fontana Thomas A Treibel Shana Tehrani Heerajnarain Bulluck Andrew S Flett Pascal Meier James Moon Derek Yellon Derek J Hausenloy

Background CMR is the imaging modality of choice to quantify myocardial injury in studies of cardioprotection. Remote ischemic conditioning (RIC), using transient limb ischemia and reperfusion, is a novel therapeutic intervention, which can protect the heart against acute ischemiareperfusion injury (IRI). Whether RIC can reduce myocardial infarct (MI) size, and improve myocardial salvage in ST-...

1999
Kimberly L. Panizzon Don Shin Sally Frautschy Roi Ann Wallis

Members of the Bcl-2 proto-oncogene family have been identified as major modulators of programmed cell death, with Bcl-2 gene products either enhancing or diminishing the likelihood of neuronal survival. This regulation appears to be essential to normal brain development, where programmed cell death may eliminate up to 50% of neurons as a part of selective pruning during formation of neuronal n...

Journal: :Journal of neurophysiology 2007
A Zsombok K M Jacobs

Structural malformations of the cortex, arising as a result of genetic mutation or injury during development are associated with dyslexia, epilepsy, and other neurological deficits. We have used a rat model of a microgyral malformation to examine mechanisms of epileptogenesis. Our previous studies showed that the frequency of miniature excitatory postsynaptic currents (mEPSCs) recorded in neoco...

Introduction: Resveratrol (3,5,4-trihydroxystilbene) a non-flavonoid polyphenol found in some plants like grapes, peanuts and pomegranates, possesses a wide range of biological effects. Evidence indicates that resveratrol has beneficial effects on nervous system to induce neuroprotection. However, the cellular mechanisms of the effects are not fully determined. In the present study, the cellula...

Journal: :Glia 2007
Dana Kurpius Eric P Nolley Michael E Dailey

Traumatic CNS injury activates and mobilizes resident parenchymal microglia (MG), which rapidly accumulate near injured neurons where they transform into phagocytes. The mechanisms underlying this rapid 'homing' in situ are unknown. Using time-lapse confocal imaging in acutely excised neonatal hippocampal slices, we show that rapid accumulation of MG near somata of injured pyramidal neurons in ...

Journal: :Photonics Research 2021

Imaging of the brain in its native state at high spatial resolution poses major challenges to visualization techniques. Two-photon microscopy integrated with thinned-skull or optical clearing skull technique provides a minimally invasive tool for vivo imaging cortex mice without activating immune response and inducing injury. However, contrast are severely compromised by heterogeneity skull, li...

Journal: :Journal of neuropathology and experimental neurology 2003
Miguel Marín-Padilla Regina J Tsai Michael A King Steven N Roper

Cortical dysplasia has a strong clinical association with epilepsy and mental retardation, but the relationship between alterations in cortical structure and function in dysplasia-related disorders is poorly understood. The cerebral cortex of irradiated rats, an experimental model of cortical dysplasia, was studied using cresyl violet-stained sections and the Golgi-Cox method. The irradiated co...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Debora Ledergerber Matthew Evan Larkum

Layer 6 (L6) pyramidal neurons are the only neocortical pyramidal cell type whose apical dendrite terminates in layer 4 rather than layer 1. Like layer 5 pyramidal neurons, they participate in a feedback loop with the thalamus and project to other cortical areas. Despite their unique location in the cortical microcircuit, synaptic integration in dendrites of L6 neurons has never been investigat...

Journal: :Indian Journal of Pharmaceutical Sciences 2023

In emergency and critical care medicine, lung ischemia-reperfusion injury is a prevalent disorder, which has significant morbidity mortality. However, there still lack of effective means to block the injury. Established model mice; histological analysis scoring were helpful assess pathological in tissue; using an enzymelinked immunosorbent assay kit, expressed interleukin-6 interleukin-1 bronch...

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