The conjugated homobimetallic palladium(II) complex [(L1)Pd(qd)Pd(L1)] (qd = quinonediimine) was obtained in a one-pot reaction by the in-situ oxidative complexation of 1,4-phenylenediamine with the palladium(II) complex [(L1)Pd(MeCN)] (H2L1 = N,N'-bis(2-phenylethyl)-2,6-pyridinedicarboxamide) while in the absence of an additional ligand [(L1)Pd(MeCN)] was converted to the amide-bridged macrocy...

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs...

Isatin is a biofactor with different biochemical and pharmacological properties whose effects attract much attention because it an endogenous inhibitor of the monoamine oxidase in brain. When exogenously administrated, isatin increases dopamine levels intact denervated striatum rats, effect that could indicate its potential as therapeutic agent Parkinson disease. However, neurochemical mechanis...

A media consisting of isatin-Schiff bases and its inclusion complexes with β-cyclodextrine was developed to maximize the production of antibiotics Hexaene H-85 and azalomycine B by Streptomyces hygroscopicus CH-7. The media with β-cyclodextrine inclusion complex of isatin-3-thiosemicarbazone resulted in the maximum antibiotics concentration of 493 μg/cm for Hexaene H-85 and 191 μg/cm for azalom...

In vivo administration of isatin (200 mg/kg) significantly lowered the activity of rat kidney alkaline phosphatase after 5 hr but enhanced the activity of rat duodenal and jejunal enzyme after 2 and 5 hr (P less than 0.01). The increased activity of the duodenal and jejunal alkaline phosphatase might be due to the induction of the enzyme by isatin.

Recently, it was proposed that neutrophils generate ozone (Wentworth, P. J., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., and Lerner, R. A. (2002) Science 298, 2195-2199; Babior, B. M., Takeuchi, C., Ruedi, J., Gutierrez, A., and Wentworth, P. J. (2003) Proc. Natl. Acad. Sci. U. S. A...

4S-ferrugineone and 4S,5S-ferrugineol as pheromones of palm weevils were synthesized in 3 and 4 steps, respectively, starting from nonane-5-one employing SAMP-/RAMP -hydrazone methodology. 5-nonanone is transformed to its corresponding RAMP hydrazone by reaction with the enantiomerically pure hydrazine RAMP. Metalation with lithium diisopropylamide (LDA) in ether to form azaenolate, followed by...

A fast and convenient protocol for the synthesis of novel spiro[dihydropyridine-oxindole] derivatives in satisfactory yields was developed by the three-component reactions of arylamine, isatin and cyclopentane-1,3-dione in acetic acid at room temperature. On the other hand the condensation of isatin with two equivalents of cyclopentane-1,3-dione gave 3,3-bis(2-hydroxy-5-oxo-cyclopent-1-enyl)oxi...

Iminoester hydrochlorides 1 have been synthesized. These compounds were then converted into ester ethoxycarbonyl hydrazones 2, from which in turn a new series of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones, 3, was then prepared. Finally a set of isatin imine derivatives 4 was obtained from the reaction of compounds 3 with isatin. The structures of all the new synthesized compounds ...

Tuberculosis (TB) remains among the world’s great public health challenges. Worldwide resurgence of TB is due to two major problems: the acquired immunodeficiency syndrome (AIDS) epidemic, which started in the mid-1980s, and the outbreak of multidrug resistant tuberculosis (MDR-TB). Thus, there is an urgent need for anti-TB drugs with improved properties such as: Enhanced activity against MDR s...