The aim of this study is to obtain polysaccharide (Glucose, Fructose and Sucrose) stabilized superparamagnetic iron oxide nanoparticles (SPIONs) by Co-Precipitation method. As prepared iron oxide nanoparticles have been characterized by X-ray Diffraction (XRD), Fourier Transform infrared (FTIR) spectroscopy, UV–Vis NIR spectroscopy, High Resolution Transmission Electron Microscope (HRTEM) and V...

BACKGROUND To compare the efficacy of oral and intravenous administration of iron supplements for treating postpartum anemia. METHODS One hundred and four anemic postpartum women were studied prospectively. The criteria for the diagnosis of anemia were Hb<8 gr/dl and ferritine<10 microg/dl. They were randomised into two groups. Group A consisted of 78 women who received i.v. a total amount of...

Background: Anemia refers to reduction in the total circulatory erythrocyte mass which results in decrease in the oxygen carrying capacity of the blood. Patients who require a surgical intervention as regards their complaints are many a times denied fitness because of anemia. Current anesthetic and surgical practice ideally recommend a hemoglobin level of > 10 g/dl or a hematocrit of >30 % for ...

Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate complex. As intravenous dextran can cause severe, antibody-mediated dextran-induced ...

Sucrofer (an Iron Sucrose complex) is one of the widely used Indian preparations for treatment of Iron deficiency anemia. The study was conducted to determine the possible efficacy and safety differences between the innovator’s Venofer and Indian similar (Sucrofer). Thirty rats were divided into three groups and assigned to receive Sucrofer, Venofer or isotonic saline solution (control). Five s...

Standard parenteral iron preparations such as ferric sucrose and ferric gluconate are considered to be degraded in the reticuloendothelial cells. The iron is subsequently incorporated into transferrin. It was also reported that these iron preparations donate iron directly to plasma transferrin. Hepatocytes seemed unaffected. We show that this picture is incorrect. To obtain quantitative data, i...

Erythropoietin combined with parenteral iron sucrose therapy is an alternative to blood transfusion in anemic patients. It was shown to be effective in surgical patients in several previous studies when used in conjunction with other methods. However, there are no guidelines about safety limits in dosage amounts or intervals. In this study, we report a case of significant postoperative hemorrha...

BACKGROUND Patients undergoing pertrochanteric hip fracture (PHF) repair surgery often receive perioperative allogeneic blood transfusions (ABTs) to avoid the deleterious effects of anemia. Nevertheless, concerns about adverse effects of ABTs have prompted the review of transfusion practice and the search for a safer treatment of perioperative anemia. MATERIAL AND METHODS The effect of preope...