OBJECTIVE The aim of this study was to summarize the interactions between hepatitis C virus (HCV) infection and iron overload, and to understand the mechanisms of iron overload in chronic hepatitis C (CHC) and the role iron plays in HCV life cycle. DATA SOURCES This review was based on data in articles published in the PubMed databases up to January 28, 2017, with the keywords "hepatitis C vi...

Iron is essential for the oxidative metabolism of lipids. Lipid metabolism changes during gestation to meet the requirements of the growing fetus and to prepare for lactation. The temporal effects of iron deficiency during gestation were studied in female rats fed complete or iron-deficient diets. Plasma triglycerides were elevated in the iron-deficient group throughout gestation. There were ti...

IT HAS BEEN KNOWN for many years that hemosiderin can be identified in the urinary sediment of patients with intravascular hemolysis,”2 and significant urinary losses of nonhemoglobin iron have been shown to occur in cases of paroxysmal nocturnal hemoglobinunia3 and sickle cell anemia.4 Since nonhemoglobin iron compounds appearing in the urine of patients with intravascular hemolysis presumably...

As our understanding of iron metabolism improves through the more accurate description of iron metabolism actors, new causes of iron overload are identified. We, here, report 16 cases of hereditary hypotransferrinemia related to 4 previously undescribed TF (transferrin) mutations (p.Val221Gly, p.Arg609Trp, p.Glu370Lys, p.Tyr533X and p.Cys421Arg). We show that, besides increasing serum transferr...

Glutamate is an excitatory transmitter and can induce neurotoxicity, it can also increase the iron concentrations in the brain, but little is known about the detailed molecular regulation mechanism of iron metabolism by Glu. Based on our previous data, iron metabolism related proteins might be associated with the increase of brain iron contents induced by neurotransmitter. To investigate the is...