نتایج جستجو برای: iron deposition
تعداد نتایج: 231843 فیلتر نتایج به سال:
AIM Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron de...
Abnormal deposition of hemichrome on the inner aspect of the sickle red cell membrane promotes premature cell demise. The steps proximate to hemichrome formation in these cells are poorly understood. To test the hypothesis that the pathologic deposits of free ferric iron located on the inner aspect of sickle cell membranes would be redox active and promote oxidation of soluble oxyhemoglobin, we...
iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. in this review, different iron chelators implicated in treatment of iron overload in various clinical conditions have been evaluated using more up-to-date studies focusing on these therapeutic agents. deferoxamine, deferiprone and deferasi...
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment a...
BACKGROUND Neurodegeneration with brain iron accumulation is a rare neurodegenerative disorder characterized by iron deposition in the basal ganglia and neuroaxonal dystrophy. Familial cases with mutations in the pantothenate kinase gene are associated with a specific phenotype. In contrast, sporadic cases are heterogeneous in their clinical presentation. OBJECTIVE To describe an atypical cas...
Background: Magnetic resonance imaging (MRI) is the best imaging examination to evaluate abnormal iron deposition in the brain. Although phase of susceptibility weighted imaging (SWI) and R2 values have been used to probe iron deposition in Alzheimer’s disease (AD) brain, no study has exploited both techniques for quantification of iron deposition in AD. Purpose: Use phase and R2 to evaluate ir...
BACKGROUND Early diagnosis of pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) has potential prognostic and therapeutic implications but can be difficult due to the lack of specific clinical manifestations or accurate non-invasive tests. Histopathologic parameters correlating with PH in IPF are also not known. Remodeling of postcapillary pulmonary vessels has been reported in ...
BACKGROUND AND PURPOSE Iron deposition and white matter (WM) maturation are very important for brain development in infants. It has been reported that the R2* and phase values originating from the gradient-echo sequence could both reflect the iron and myelination. The aim of this study was to investigate age-related changes of R2* and phase value, and compare their performances for monitoring i...
DEAR EDITOR, We read with respect the paper “Protective role of Silymarin and deferoxamine against iron dextran induced renal iron deposition in male rats by Nematbakhsh et al. It is an interesting paper; however, I would like to add some complementary comments to it. In this paper the Silymarin reduced the kidney iron deposition in an iron overload model. The findings have demonstrated that Si...
[1] Aeolian dust input may be a critical source of dissolved iron for phytoplankton growth in some oceanic regions. We used an atmospheric general circulation model (GCM) to simulate dust transport and removal by dry and wet deposition. Model results show extremely low dust concentrations over the equatorial Pacific and Southern Ocean. We find that wet deposition through precipitation scavengin...
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