Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revea...

Bare root transplants of strawberry (Fragaria x ananassa Duch. cv. ‘Selva’) were transferred to nutrient solutions with or without iron (Fe). After six weeks of growth, plants in the solution without Fe were chlorotic and had morphological changes in roots typical of Fe deficiency. At this point, four treatments were imposed with three replicates (plants) each: plants always grown without Fe (F...

The purpose of this study was to investigate the response of physicochemical properties of gerbera (Gerbera Jamesonii L.) to silica nanoparticles (Nanoparticle-SiO2) and calcium chelate (Ca-Chelate) in nutrient solutions. A factorial experiment based on completely randomized design with two factors was conducted in four replicates. The first factor the concentration of Nanoparticle-SiO2 in nutr...

Fe(III) oxides hydrated to various extents are the most abundant iron species in soil. Their extremely low solubility makes them almost unavailable to living organisms. To cope with iron deficiency, many microorganisms synthesize and secrete siderophores [1–5], which are low-molecular-weight compounds that specifically chelate Fe(III) to form stable complexes, into the soil (association constan...

Previous studies documented the abnormal association of heme and heme proteins with the sickle RBC membrane. We have now examined RBC ghosts and inside-out membranes (IOM) for the presence of nonheme iron as detected by its formation of a colored complex with ferrozine. Sickle ghosts have 33.8 +/- 18.2 nmol nonheme iron/mg membrane protein, and sickle IOM have 4.3 +/- 3.0 nmol/mg. In contrast, ...

Precious metal complexes with the d6 valence electron configuration often exhibit luminescent metal-to-ligand charge transfer (MLCT) excited states, which form basis for many applications in lighting, sensing, solar cells and synthetic photochemistry. Iron(ii) has received much attention as a possible Earth-abundant alternative, but to date no iron(ii) complex been reported show MLCT emission u...

iron deficiency in soil reduces the quality of durum wheat leading to fe deficiency in human. thus, this experiment investigated the effects of foliar application of nano-iron oxide (2 and 4 g l-1), iron chelate (edta), (4 and 8 g l-1), iron sulfate (4 and 8 g l-1), and the control on grain yield and quality, yield components, chlorophyll and carotenoids contents, peroxidase (pox), catalase (ca...

Interaction between apo-transferrin and several iron(III) chelates has been investigated in terms of the capillary electrophoresis method. Based on the results, it has been clarified that (i) a binuclear iron(III) unit with an oxo-bridge is necessary for the facile transfer of an iron atom from the iron(III) chelate to apo-transferrin, and (ii) the renal proximal tubular injuries by Fe(III)-nit...

Cold plasma and ozone sanitation of irrigation solutions can oxidize both microbes non-target micronutrients because their high oxidation-reduction potential (ORP) is a non-selective mode action. The objective this study was to evaluate the effects cold treatment on oxidation iron manganese in nutrient containing one four chelates (iron-ethylenediaminetetraacetic acid (Fe-EDTA), iron-diethylene...