Moron et al.: Genome Medicine 2009, 1:76 Abstract The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause coul...

Menopause is an endocrinological transition that greatly affects health and disease susceptibility in middle-aged and elderly women. To gain new insights into the metabolic process of menopause, plasma metabolic profiles in 115 pre- and post-menopausal women were systematically analyzed by ultra-performance liquid chromatography/mass spectrometry in conjunction with univariate and multivariate ...

objective: a magnesium deficiency is known to be involved in many abnormalities in the post-menopausal women. previous studies proposed that magnesium (mg) might prevent atherosclerosis. in this study the efficacy of serum magnesium level and its relation with carotid intima media thickness (cimt) in post-menopausal women was evaluated. methods: eighty iranian postmenopausal women were included...

results the mean age of the respondents was 52.27 years (sd = 3.84). the average scores of their vasomotor, psychosocial, physical, and sexual dimensions were 3.86, 2.30, 2.44, and 1.35, respectively. sociodemographic dimensions, such as smaller age, being married, having a lower education level, and having a higher number of children, were related to sexual symptoms. vasomotor symptoms were re...

BACKGROUND The age in menopause and frequency of menopausal symptoms differ in different societies. This study evaluates the distribution of age at normal menopause, the frequency of menopausal symptoms and the associated factors in Babol, Northern Iran. METHODS In a community based study, the Symptom Score Card was used to assess the frequency and severity of menopausal symptoms. Data from 1...

Background Sexual problems are common among the middle-aged women; however, there is no deep understanding of sexuality in midlife. The current study aimed to investigate Iranian women's attitudes and experiences about sexual life changes in midlife. Methods This is a descriptive qualitative study. Seventeen women aged 40 -65 years old were purposively selected from urban health centers in Go...

CONTEXT Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer. OBJECTIVE To assess the associations of adult weight change since age 18 years and since menopause with the risk of breast cancer among postmenopausal women. DESIGN, SETTING, AND PARTICIPANTS Pr...

Historically, menopause research has developed mainly on the basis of endocrinological issues and research findings. The studies dealt primarily with the widespread complaints that women suffer in association with the menopause, with the intention of serv­ ing medical practice as directly as pos­ sible. In 1870, a woman’s mean remaining life expectancy by the time her young­ est child left home...

Since the implementation of effective combination antiretroviral therapy, HIV infection has been transformed from a life-threatening condition into a chronic disease. As people with HIV are living longer, aging and its associated manifestations have become key priorities as part of HIV care. For women with HIV, menopause is an important part of aging to consider. Women currently represent more ...