In 2000 three Carbon beam blocks were used to treat 32 patients suffering from skull base tumors such as chordomas, chondrosarcomas, adenoid cystic carcinomas and other less frequent indications. Partially these ongoing clinical trials have reached phase II level. In total 73 patients have been treated within this experimental programme and the overwhelming part of treatments had a curative int...

In this paper we report on first results obtained using polycrystalline CVD diamond detectors irradiated with heavily ionizing particles at GSI. At the UNILAC accelerator, ions with energies near the Bragg-Peak have been stopped inside the material whereas at the heavy-ion therapy facility of GSI these detectors are operated in transmission mode and have been studied in a carbon beam from SIS w...

Ameloblastic carcinomas are rare odontogenic tumors. Treatment usually consists of surgical resection and sometimes adjuvant radiation. We report the case of a 71 year-old male patient undergoing carbon ion therapy for extensive local relapse of ameloblastic carcinoma. Treatment outcome was favourable with a complete remission at 6 weeks post completion of radiotherapy while RT-treatment itself...

Motivation Cancer is the second most frequent cause for disease in the developed countries. Every year, more than 1 million people in the European Union are diagnosed of having cancer. A general cure of cancer is not in sight because the term cancer stands for a large variety of diseases that can be characterised by an uncontrolled cell growth. Normally, cell growth is regulated by a number of ...

In treatment of motion affected tumours by means of a scanned particle beam severe under and over dosage can occur due to the interplay effect. By using gated beam delivery effective target motion is reduced, but even for the residual motion the interplay effect can lead to unsatisfactory dose distributions. Furthermore, an appropriate motion monitoring system is essential since beam delivery h...

The large interest in heavy-ion therapy is stimulated from its excellent clinical results. The bases of this success are the radiobiological and physical advantages of heavy-ion beams and the active beam delivery used for an intensity-modulated particle radiotherapy (IMPT). Although heavy-ion therapy has reached a high degree of perfection for clinical use there is still large progress possible...

Cancer is a leading cause of death in the world. Conventional treatments have severe side effects and low survival rate. It is important to discover new targets and therapeutic strategies to improve the clinical outcomes of cancer patients. Ion channels are specialized membrane proteins that play important roles in various physiological processes. Recent studies have shown that abnormal express...

These innovations have been the result of a long standing research and development in radiobiological and physical experiments, design and construction of a dedicated fast magnetic deflection system and its electronic control , treatment planning and accelerator developments. From the beginning of the pilot project all these innovations were available and used without any major restriction. Tre...

Photodynamic Therapy In article number 2100789 by Jinsheng Shi, Xiaoying Kong, and co-workers, the combined strategy of UCRSPH SA CaO2 nano platform achieves application self reinforcing PDT, Ca2+ ion interference therapy multi means in situ imaging diagnosis treatment tumors, which is great significance for improving clinical therapeutic effect tumors precise tumor vivo.