A surface ionization (SI) source was designed and constructed for ion mobility spectrometry (IMS). Compared with a conventional (63)Ni source, the surface ionization source is as simple and reliable, has an extended dynamic response range, is more selective in response, and does not have regulatory problems associated with radioactive ionization sources. The performance of this SI-IMS was evalu...

Multidimensional ion mobility spectrometry techniques (IMS-IMS and IMS-IMS-IMS) combined with mass spectrometry are used to study structural transitions of ubiquitin ions in the gas phase. It is possible to select and activate narrow distributions of compact and partially folded conformation types and examine new distributions of structures that are formed. Different compact conformations unfol...

Abstract Headspace-gas-chromatography ion-mobility spectrometry (HS-GC-IMS) proved the diversity of volatile chlorinated compounds (VCCs) in frying oil this work. First, VCCs were obtained by headspace heating at 80 °C for 30 min. Then, those separated GC capillary column first dimension and IMS second dimension, respectively. And last, detected negative ion mode non-targeting. The study result...

Gas-phase ion mobility studies of mixtures containing polyethylene glycols (PEG) and an active pharmaceutical ingredient (API), lamivudine, have been carried out using electrospray ionization-ion mobility spectrometry-quadrupole-time-of-flight mass spectrometry (ESI-IMS-Q-TOF). In addition to protonated and cationized PEG oligomers, a series of high molecular weight ions were observed and ident...

This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for analysis of biological samples. The determination endogenous and exogenous compounds in such samples is important understanding health status individuals. For this reason, development new approaches that can be complementary ones already established (mainly liquid chromatography coupled mass spectrometry) ...

Benzodiazepines are a commonly abused class of drugs; requiring analytical techniques that can separate and detect the drugs in a rapid time period. In this paper, the two-dimensional separation of five benzodiazepines was shown by electrospray ionization (ESI) ion mobility spectrometry (IMS)–mass spectrometry (MS). In this study, both the two dimensions of separation (m/z and mobility) and the...

Abstract Gas chromatography-ion mobility spectrometry (GC-IMS) is an emerging analytical technique that has the advantages of fast response, high sensitivity, simple operation, and low cost. The combination speed resolution GC with sensitivity IMS makes GC-IMS play important role in detection food volatile substances. This paper focuses on basic principles future development trend, comparative ...

The analysis of explosives with ion mobility spectrometry (IMS) directly from aqueous solutions was shown for the first time using an electrospray ionization technique. The IMS was operated in the negative mode at 250 degrees C and coupled with a quadrupole mass spectrometer to identify the observed IMS peaks. The IMS response characteristics of trinitrotoluene (TNT), 2,4-dinitrotoluene (2,4-DN...