When birth weight for gestation is used as a surrogate for intrauterine growth, the prevalence of cerebral palsy varies continuously in a reversed J shape, with steep increases in the risk for infants lighter and heavier than the optimum size. Patterns of size-at-birth specific risk for cerebral palsy differ between male and female infants, as do the patterns for more severe versus milder cases...

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association. Pre-eclampsia and intrauterine growth restriction remain important causes of maternal and neonatal complications and death. These 2 conditions are felt to be the result of abnormal placenta formation involving abnormal trophoblast invasion of spiral arteries and a r...

EFFICACY OF INTRAUTERINE INSTILLATION AUTOLOGOUS PLATELET-RICH PLASMA ON ENDOMETRIAL GROWTH DURING THE FROZEN-THAWED EMBRYO TRANSFER CYCLES

OBJECTIVES To investigate whether, in women with abnormal uterine artery Doppler, platelet volume and function will identify a subgroup of women at increased risk of pre-eclampsia and intrauterine growth restriction and whether in-vitro platelet aggregation precedes the onset of clinical disease. DESIGN Platelet number, volume and aggregation induced by collagen or adenosine 5'-diphosphate we...

Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve his/her intrinsic growth potential, due to anatomical and/or functional disorders and diseases in the feto-placental-maternal unit. IUGR results in significant perinatal and long-term complications, including the development of insulin resistance/metabolic syndrome in adulthood. The thrifty phenotype hypothesis holds ...