Introduction: The use of epidural analgesia in patients with implanted intrathecal delivery devices is somewhat controversial. Major concerns include the risk of damaging the intrathecal catheter, the risk of infection, and the potential for interaction between the epidurally-administered and the intrathecally-delivered medication. In children with cerebral palsy, intrathecal administration of ...

: 25 Spinal anesthesia for cesarean delivery: Study of equivalence using bupivacaine with or without fentanyl Presenting Author: Rachel A Meyer BSc, MD Presenting Author's Institution: University of Toronto Toronto, Ontario Co-Authors: Alison J Macarthur BMSc, MSc, MD Mount Sinai Hospital Toronto, Ontario Kristi Downey MSc Mount Sinai Hospital Toronto, Ontario Abstract Body: Spinal anesthesia i...

Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques. A novel drug delivery system (DDS) is being developed in our laboratory that can provide localized release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, and biocompatible as an injectable intrathecal DDS. A gel that meets these design criteria...

ber 1999) that demonstrate little difference in dermatomal spread in CSF of fentanyl compared with morphine after intrathecal injection. Thus, the extrapolation from pigs to humans and from models of CSF and tissue kinetics to clinical effects is far from certain. In summary, the article by Ummenhofer et al. is a seminal work in intrathecal pharmacokinetics. It directly incorporates location in...

BACKGROUND Breech presentation is a leading cause of cesarean delivery. The use of neuraxial anesthesia increases the success rate of external cephalic version procedures for breech presentation and reduces cesarean delivery rates for fetal malpresentation. Meta-analysis suggests that higher-dose neuraxial techniques increase external cephalic version success to a greater extent than lower-dose...