نتایج جستجو برای: intracellular synthesis gabaa receptor

تعداد نتایج: 1076739  

Journal: :iranian journal of basic medical sciences 0
sayed rasul zaker department of biology, faculty of sciences, university of isfahan, isfahan, iran abolghasem esmaeili department of biology, faculty of sciences, university of isfahan, isfahan, iran department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran majid bouzari department of biology, faculty of sciences, university of isfahan, isfahan, iran elham shirani department of biology, faculty of sciences, university of isfahan, isfahan, iran department of biotechnology, faculty of advanced sciences and technologies, university of isfahan, isfahan, iran

objective(s) in this study we investigated the expression of gabaa receptor subunits during brain development. these receptors may change in the embryonic chick forebrain. materials and methodes the expression levels of four types of gabaa receptor gamma subunits (γ1, γ2, γ3 and γ4) were quantified in the embryonic chick forebrain at 32 hr, 3, 7, 14, and 20 days of incubation and day one after ...

M Abasnejad M Rezvanipour T Safari

In the present study, the effects of intracuneiformis nucleus microinjection of gamma-aminobutyric acidA (GABAA) receptor agonist and antagonist on antinociception inducced by morphine were investigated with formalin test in rat. Intracuneiformis nucleus microinjection of morphine (10µgr/rat) and Bicuculline (50, 100 ng/rat) induced antinociception in the both first and second phases of formali...

Background γ-Aminobutyric acid (GABA) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (CNS). There are two major classes of GABA receptors: GABAARs and GABABRs. The GABAA receptor is derived from various subunits such as alpha1-alpha 6, beta1-beta 3, gamma1-gamma 4, delta, epsilon, pi, and rho1-3. Intensive research has been performed to und...

Journal: :South African Dental Journal 2023

Background. Bruxism is a phenomenon where psychological and exogenous biological factors act in greater percentage. Several genetic polymorphisms have been described GABAA receptors, some associated with motor limitations, such as the rs1805057 polymorphism of GABRB1 gene (GABAA), which found haplotype lower limitation movement acute pain processes. The aim to identify clinical phenotypes bruxi...

2001
Rochelle D. Schwartz-Bloom Renu Sah

In this review, we present evidence for the role of g-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death. While glutamate neurotransmission has received widespread attention in this area of study, relatively few investigators have focused on the ischemia-induced alterations in inhibitory neurotransmission. We present a review of the effects of cerebral ischem...

Journal: :Journal of neurochemistry 2006
Waltraud Ogris Reinhard Lehner Karoline Fuchs Birgit Furtmüller Harald Höger Gregg E Homanics Werner Sieghart

In cerebellum, 75% of all GABAA receptors contain alpha1 subunits. Here, we investigated compensatory changes in GABAA receptor subunit expression and composition in alpha1 subunit-knockout mice. In these mice the total number of cerebellar GABAA receptors was reduced by 46%. Whereas the number of receptors containing alpha6 subunits was unchanged, the total amount of alpha6 subunits was signif...

2015
Daniel Ulrich

Amyloid (A ) is thought to play an important role in the pathogenesis of Alzheimer’s disease. A may exert its neurotoxic effects via multiple mechanisms and in particular through degradation of excitatory synaptic transmission associated with impaired synaptic plasticity. In contrast, much less is known about A effects at inhibitory synapses. This study investigates the impact of acute A 1-42 a...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2015
George Gallos Gene T Yocum Matthew E Siviski Peter D Yim Xiao Wen Fu Michael M Poe James M Cook Neil Harrison Jose Perez-Zoghbi Charles W Emala

The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases remains a major medical issue. Modulation of airway smooth muscle (ASM) chloride via GABAA receptor activation to achieve relaxation of precontracted ASM represents a potentially beneficial therapeutic option. Since human ASM GABAA receptors express only the α4- and α5-subunits, there is an opportunity...

Abolghasem Esmaeili, Elham Shirani Majid Bouzari, Sayed Rasul Zaker

Objective(s) In this study we investigated the expression of GABAA receptor subunits during brain development. These receptors may change in the embryonic chick forebrain. Materials and Methodes The expression levels of four types of GABAA receptor gamma subunits (γ1, γ2, γ3 and γ4) were quantified in the embryonic chick forebrain at 32 hr, 3, 7, 14, and 20 days of incubation and day one aft...

2016
Damien E. Earl David R. Giovannucci Bryan K. Yamamoto

..................................................................................................................... iii ACKNOWLEDGEMENTS ..............................................................................................v TABLE OF CONTENTS ............................................................................................... vii LIST OF TABLES ................................

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