Thresholds for retinal vitreal and contained hemorrhages were determined for 1064 nm laser light at 30-nsec and 4-nsec pulsewidths. Rhesus monkeys received graded exposures from a neodymium-yag laser onto either the macular or extramacular region of the retina. Contained hemorrhages appeared as concentric ring structures with white punctate centers. The vitreal hemorrhage was characterized by t...

Advances in pharmacological agents and surgical and laser technology have had significant effects on the practice of ophthalmology in recent years. The widespread recognition and use of anti‐vascular endothelial growth factor (anti‐VEGF) drugs, as intravitreal injections, started with the treatment of age related macular degeneration (ARMD) several years ago. This is now standard treatment and ...

Diabetic retinopathy (DR) is the main cause of visual impairment in industrialized countries. Great efforts are in place to search for new therapies able to prevent the development of DR and the onset of its complications. At present, therapy consists of anti-VEGF intra vitreal injections and is aimed at preventing the main causes of visual impairment, that is, macular oedema and retinal prolif...

background: implantation remains a limiting step in ivf/icsi. endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after ivf/icsi. objective: the aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on ivf/icsi outcome. materials and methods: four hundred patients undergoing their first ivf/icsi cycle in two ...

the present study was designed to explore the anti-inflammatory effect of fluvoxamine, as a selective serotonin reuptake inhibitor (ssri) anti-depressant, on carrageenan-induced paw edema in more details. at first, fluvoxamine was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg kg-1) 30 min before the subplantar injection of carrageenan. fluvoxamine was also injected intra-peritoneally...

The objective of the present study was to investigate the effect of topically coadministered P-glycoprotein (P-gp) substrates/inhibitors on the vitreal kinetics of a systemically administered P-gp substrate. Anesthetized male rabbits were used in these studies. The concentration-time profile of quinidine in the vitreous humor, after intravenous administration, was determined alone and in the pr...

Diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. It is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. It is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...

we reported a 35 year old breast cancer patient who was referred to our nuclear medicine department for sentinel node mapping. she was planned to undergo mastectomy and lymphatic mapping. a dose of tc-99m phytate was injection in the peri-areolar region in an intra-dermal fashion. two hours post-injection no sentinel node was visible in the axilla. due to a high liver uptake, inadvertent intra-...