PURPOSE To evaluate the effectiveness of intraarticular tranexamic acid (TXA) in reducing blood loss and the need for blood transfusion during total hip arthroplasty (THA). METHODS Records of 19 men and 31 women aged 46 to 83 (mean, 62) years who underwent primary THA with intra-articular administration of TXA were reviewed. They were compared with a matched cohort of 17 men and 33 women aged...

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Background: Tranexamic acid (TXA) is effective in reduction of blood loss after major surgical procedures. In TKA surgeries, it commonly administered intravenously. Since there are contraindications systemic use TXA, local/intraarticular TXA can also be used. The efficacy both and local administration demonstrated the literature. aim was to assess effect intraarticular during total knee arthrop...

Introduction: Angiogenesis is an important factor in the development of osteoarthritis (OA). Angiogenesis also results in innervation of the articular cartilage (1), which may provide the possible source of pain in OA patients. We reported previously that intravenous administration of bevacizumab, a humanized monoclonal anti-VEGF antibody, contributes to the repair of articular cartilage in an ...

The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocentesis procedure was carried out. In one group, the procedure was followed by the...

The influence of circulating serotonin (5-HT) on the effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously. The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT be...

BACKGROUND & OBJECTIVES Effective pain control following outpatient surgical procedures is an important aspect of patient discharge. This study was carried out with an aim to investigate the histopathological effects of intra-articular dexketoprofen trometamol injection in knee joint on synovium and cartilage in an experimental rat model. METHODS In each of 40 rats, the right knee was designa...