نتایج جستجو برای: intestinal polyposis
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Serrated polyposis has only recently been accepted as a condition which carries an increased personal and familial risk of colorectal cancer. Described over four decades ago, it remains one of the most underrecognized and poorly understood of all the intestinal polyposes. With a variety of phenotypic presentations, it is likely that serrated polyposis represents a group of diseases rather than ...
Juvenile polyps of the duodenum are rare and nearly always occur in the context of a more widespread gastrointestinal juvenile polyposis. Clinical features and neoplastic risk are less significant, although there is a case report of a duodenal carcinoma occurring in a patient with familial juvenile polyposis. Most of the polyps resemble the more common sporadic juvenile polyp of the colon, bein...
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Attenuated familial adenomatous polyposis (AFAP) is a subtype of a condition known as familial adenomatous polyposis [2] (called FAP or classic FAP). People with FAP or AFAP will have an increased number of adenomatous colon polyps during their lifetime and an increased risk of developing colorectal cancer [3]. An adenomatous polyp is a lump filled with the cells that make mucous and line the i...
Colon cancer in humans is influenced by both genetic and dietary risk factors. The majority of colon cancers have somatic mutations in the APC (adenomatous polyposis coli) tumour-suppressor gene. Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models by a mechanism involving NOS2 (nitric oxide synthase 2), as elimination of NOS2 alleles suppresses this phenotyp...
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (CRC). FAP is characterized by multiple intestinal adenomas, which inexorably result in CRC. Surprisingly, given their common occurrence, there...
Interactions between the epithelium and surrounding mesenchyme/stroma play an important role in normal gut morphogenesis, the epithelial response to injury, and epithelial carcinogenesis. The tumor microenvironment, composed of stromal cells including myofibroblasts and immune cells, regulates tumor growth and the cancer stem cell niche. Deletion of epimorphin (Epim), a syntaxin family member e...
Weber (1919) described a case of acute intussusception in one of a pair of twins originally noticed by Hutchinson (1896) to have oral pigmentation. Peutz (1921) recorded a family of seven, and Jeghers, McKusick and Katz (1949) reported 10 cases of melanosis of the lips and buccal mucosa together with polyposis of the gastro-intestinal tract. The latter's report included a review of the literatu...
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