Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties. Extending previous data, IDR-1002 suppressed in vitro inflammatory responses in RAW 264.7 murine monocyte/macrophage cells challenged with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan. To investigate the anti-inflammatory mechanisms of IDR-...

Due to the isochronous nature of multimedia streams, jitter management; represents a major challenge to synchronized and timely presentation of multimedia documents. For controlling jitter, we propose the Initial Delay Regulator (IDR). This regulator is based on a network model which abstracts jitter parameters inside a data network. As a result of employing such a regulator, jitter at the dest...

Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in end...

The recently proposed method IDR(s) [6] for solving large and sparse nonsymmetric systems of linear equations has proven to be highly efficient for important classes of applications. This paper presents an performance comparison of IDR(s) with GMRES [3], Bi-CGSTAB [7] and BiCGstab(l) [4] for representative fluid dynamics test problems. The computations are done with the MATLAB finite element pr...

Bernstein’s inequality for Legendre polynomials Pn, as generalized by Baratella, Chow, Gatteschi, and Wong to Jacobi polynomials P n , (α, β) ∈ calR1/2 = {|α| ≤ 1/2, |β| ≤ 1/2}, is analyzed analytically and computationally with regard to validity and sharpness in larger domains Rs = {−1/2 ≤ α ≤ s,−1/2 ≤ β ≤ s}, s > 1/2. Title: Bivariate B-splines used as basis functions for data fitting Speaker...

A major factor in limiting the efficacy of anthracyclines is overexpression of the MDR1-encoded p-glycoprotein (p-gp). A new analogue less affected by p-gp is annamycin (ANN), an anthracycline antibiotic with high affinity for lipid membranes and significantly more activity than doxorubicin (DOX). We investigated whether ANN was affected by p-gp-mediated multidrug resistance (MDR) by comparing ...

We discuss the impacts of COVID-19 pandemic on Indonesia’s financial markets and monetary policy dynamics. explore five types in Indonesia: (1) Rupiah (IDR) interbank money market; (2) US Dollar (USD) (3) government conventional bond (SUN) markets; (4) stock (5) USD/IDR spot market. examine Bank (BI)'s three instruments: BI 7-day Reverse Repo Rate (the rate); minimum reserve requirement ratios ...

Background • The IDR(s) was introduced for solving linear systems in [3]. • IDR(s) creates residual vectors in the nested and shrinking subspaces Gj defined as Gj ≡ (A− μjI)(Gj−1 ∩ P⊥) j = 1, 2, . . . where P ∈ Cn×s and G0 ≡ C; in order to extract the approximated solution. • First IDR(s) method to solve Eq. (1) was proposed by M. H. Gutknecht and J.-P. M. Zemke [2]. The work we present here is...

The IDR(s) method that is proposed in [7] is a very competitive limited memory method for solving large nonsymmetric systems of linear equations. IDR(s) is based on the induced dimension reduction theorem, that provides a way to construct subsequent residuals that lie in a sequence of shrinking subspaces. The IDR(s) algorithm that is given in [7] is a direct translation of the theorem into an a...

Welcome readers to Infectious Disease Reports (IDR). IDR was established in 2009 as an Open Access, peer-reviewed, online-only journal of infectious disease research and practice. I am delighted that over the past year IDR has made significant advances in reaching out “across geographical, cultural, and political barriers to communicate about the latest infectious disease problems and solutions...