Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic fibrosing interstitial lung disease associated with pattern Usual Interstitial Pneumonia (UIP) based on CT appearances or histology.

Idiopathic interstitial pneumonias are currently classified into four categories: usual interstitial pneumonia, nonspecific interstitial pneumonia with fibrosis, acute interstitial pneumonia and desquamative interstitial pneumonia. The fibrotic process in interstitial pneumonias appears to result from a complex interaction between fibroblasts, other lung parenchymal cells and macrophages. The c...

objective(s):our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(tgf-β1), α-smooth muscle actin (α-sma) and alleviating interstitial fibrosis following unilateral ureteral obstruction (uuo). in this study, we investigate the effect of breviscapine on changes of renal water and sodium transport proteins in response t...

PURPOSE OF REVIEW After briefly discussing several ways to approach airway involvement in interstitial lung diseases - by diagnostic methodologies used to assess it, considering different topographical involvement, related to its presence in the diffuse lung diseases with higher prevalence, or from a causal point of view - the author describes in more detail, taking into account recent literatu...

Substitutional carbon is known to locally reduce silicon self-interstitial concentrations and act as a barrier to self-interstitial migration through the carbon rich regions. A silicon spacer between two carbon rich SiGe layers is fabricated in this work to examine self-interstitial generation in a region that is isolated from self-interstitial formation at the surface or in the silicon bulk. B...

This paper will discuss the recent finding that the normal interstitial fluid pressure is negative rather than positive and will present a method for recording dynamic changes in interstitial fluid pressure. Especially important is the shape of the pressure-volume curve of the interstitial spaces. So long as the interstitial fluid pressure is negative, the interstitial fluid volume remains almo...

PURPOSE We investigated the role of Tamm-Horsfall protein in interstitial cystitis. MATERIALS AND METHODS Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein. RESULTS Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statis...

Chimeric hydra were prepared by recombining epithelial and interstitial cells between 3 strains of hydra of different sizes (maxi, normal, and mini strains). The resulting chimeras generally resembled the epithelial cell parent more than the interstitial cell parent in size, budding rate, tentacle number, and form. This suggests that epithelial cells normally exert considerable influence over h...

OBJECTIVE To elucidate the patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma, we reviewed seven cases of everolimus-induced interstitial lung disease. METHODS Seven patients with metastatic renal cell carcinoma, which continued to progress despite treatment with sunitinib or sorafenib, developed interstitial lung disease after t...

Exercise-induced hypoxia is an index of the severity of interstitial lung disease. We hypothesized that desaturation during a 6-minute walk test would predict mortality for patients with usual interstitial pneumonia (n = 83) and nonspecific interstitial pneumonia (n = 22). Consecutive patients with biopsy-proven disease performed a 6-minute walk test between January 1996 and December 2001. Desa...