In the WVhitehall study, 18,388 subjects aged 40-64 years completed a questionnaire on intermittent claudication. Of these subjects, 0.8% (147) and 1% (175) were deemed to have probable intermittent claudication and possible intermittent claudication, respectively. Within the 17-year follow-up period, 38% and 40% of the probable and possible cases, respectively, died. Compared with subjects wit...

BACKGROUND Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease, that develops in a limb during exercise and is relieved with rest. Buflomedil is a vasoactive agent used to treat peripheral vascular disease. However, its clinical efficacy for IC has not yet been critically examined. This is an update of a Cochrane review first published in 2000, and previously upd...

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OBJECTIVE Remote ischemic preconditioning (RIPC) is a phenomenon in which a short period of sub-lethal ischemia in one organ protects against subsequent bouts of ischemia in another organ. We hypothesized that RIPC in patients with intermittent claudication would increase muscle tissue resistance to ischemia, thereby resulting in an increased ability to walk. METHODS In a claudication clinic,...

The arm-ankle systolic pressure gradient was measured in 165 male patients with intermittent claudication and was correlated with different combinations of known cardiovascular risk factors. The pressure gradient increased with increasing number of risk factors. We conclude that intermittent claudication may be used as a simple model for studies of arteriosclerosis, the arm-ankle systolic press...

[We gladly avail ourselves of an opportunity afforded by the kindness of Mr. Turnbull of laying before our readers a translation of Salvatori's celebrated dissertation on Drunkenness?a dissertation little kuown in this country from the great scarcity and difficulty of access of the volume in which it originally appeared. This essay is of rare interest to the medical scholar, not only because in...

BACKGROUND The use of physical training in the treatment of intermittent claudication is well established. However, current data do not provide enough information about the prognosis for each case, and there are no data on how walking distances evolve over time with conservative treatment. The goal of this study was to evaluate improvement in walking capacity among patients with intermittent cl...

Intermittent claudication is a common manifestation of peripheral arterial disease, its symptoms have a gradual onset and the patient may not notice them initially, instead accepting them as part of the ageing process. The main concern with intermittent claudication is the increased risk of cardiovascular or cerebrovascular events. This article highlights the relationship between these diseases...

'Intermittent claudication' of the spinal cord was first described by Dejerine in 1911. In 1961, Blau and Logue described an unsual syndrome resulting from central protrusion of a lumbar intervertebral disc which gave rise to symptoms suggesting 'intermittent claudication of the cauda equina'. Since this report, a further series of cases has been described by Evans (1964). We have recently obse...