background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptib...

Background: The tumor necrosis factor alpha (TNFα) is a cytokine that produced principally by monocyte/macrophages and T lymphocytes, respectively. TNFα is recognized as the primary mediator of immunity in inflammation reaction.  One important application of Tumor Necrosis Factor Receptor 2 (TNFR2) is for the treatment of autoimmune diseases like rheumatoid arthritis (RA).<br /...

Abstract The aim of this study is to identify the active compounds essential oil extracted from Pinus densiflora (Sieb. et Zucc.) wood using hydrodistillation method and evaluate their anti-inflammatory activity. chemical composition was identified by GC–MS analysis, its activity assessed investigating effect on expression interleukin-4 (IL-4), interleukin-13 (IL-13), ? -hexosaminidase in lipop...

Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is an allergic response characterized by type 2 inflammatory reactions mediated T helper cells (Th2). Th2 elevated cytokines related to the humoral response, including Interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10, IL-13, IL-25 and IL-33. Allergic fungal sinusitis (AFS) a distinguishable form of CRSwNP primary localized disea...

conclusions these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection. results persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the ...

background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cyt...

traumatic brain injury is a leading cause of disability and death from injury in the world. the interleukin-1 (il-1) is a family of cytokines that act as key mediators of the inflammatory response peripherally and centrally. based on many studies, researchers found that the il-1 is the well-known molecule in relation to acute tbi in the models of both focal and diffuse injuries. the il-1 family...