نتایج جستجو برای: interleukin 7 receptor alpha multiple sclerosis
تعداد نتایج: 2088242 فیلتر نتایج به سال:
Background and Objective: Multiple Sclerosis (MS) is a neurological disorder that can restrict individual's ability to carry on their activities. The[J1] aim of this study was to examine the effects of combined exercise training on serum Fibrin D-Dimer (FDD) and interleukin-6 in female multiple sclerosis patients with different levels of disability. Materials and Methods: 96 female patients ...
abstract aim and background: the purpose of the present study was to examine the psychometric properties of multiple sclerosis self-efficacy scale (msss) in a sample population of iranian patients. methods and materials: this research is a descriptive-correlational study with a population of patients afflicted with ms from north khorasan and hamedan provinces. a number of 120 patients, who had ...
Interleukin 7 (IL-7) is an essential cytokine that acts as a potent growth factor of T-cells and supports the B-cell precursors. IL-7 binds to heterodimeric receptor consisting alpha (IL-7Rα) common gamma chain (γc) which shared with IL-2, IL-4, IL-9, IL-15 IL-21. The discovery small-molecule agonists cytokines would be great pharmaceutical interest increasing scientific rationale. In this stud...
In multiple sclerosis, encephalitogenic CD4(+) lymphocytes require adhesion molecules to accumulate into central nervous system inflammatory lesions. Using proteomic techniques, we identified expression of melanoma cell adhesion molecule (MCAM) on a subset of human effector memory CD4(+) lymphocytes and on human blood-brain barrier endothelium. Herein, we demonstrate that MCAM is a stable surfa...
Relatively little is known about the relationship of lymphoid-associated gene expression to the proliferation and differentiation potential of early human bone marrow lymphoid progenitors. Surface expression of interleukin-7 (IL-7) receptor-alpha (IL-7R alpha), a component of the high-affinity receptor for the lymphoid precursor growth factor IL-7, defined a CD34+ progenitor subset lacking the ...
Several abnormalities of cytokines have been shown to occur in systemic scleroderma; however their correlation with clinical parameters is controversial. Since serum concentrations of cytokine receptors have been shown to correlate with inflammatory processes, including systemic sclerosis, the aim of our study was to compare serum concentrations of TNF alpha receptor type 1 with the concentrati...
BACKGROUND We have previously shown that the inducible kinin B(1) receptor is expressed on T lymphocytes during relapses and progression in multiple sclerosis. OBJECTIVE To evaluate the correlation between the expression of B1 receptor on peripheral blood mononuclear cells derived from patients who have multiple sclerosis with serial, clinical magnetic resonance imaging and immunological stud...
Recent approval of the anti-interleukin (IL)-6 receptor antibody tocilizumab by US Food and Drug Administration (FDA) for slowing rate decline in pulmonary function adult patients with systemic sclerosis-associated interstitial lung disease is a welcome step towards better treatment outcomes sclerosis. Systemic has emerged as one major causes death very high burden unmet need. Tocilizumab secon...
we have reviewed the medical records of 40 patients with disseminated (bacille calmette-guerin) bcg from 1996 to 1999 in the immunology department of the children hospital, medical center, tehran university. these patients are divided in to 3 groups: 1. patients who had disseminated (bacille calmette-guerin) bcg after vaccination and their diagnosis was chronic granulomatous disease. 2. patient...
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