Interleukin-6 (IL-6) spielt eine wichtige Rolle bei der Pathogenese rheumatoiden Arthritis (RA). Mittlerweile sind gegen den IL-6-Signalweg gerichtete monoklonale Antikörper (z. B. Sarilumab) zur Therapie RA zugelassen. Lässt sich anhand des initialen IL-6-Serumspiegels das Therapieansprechen voraussagen? Dieser Frage ging ein Team internationaler Wissenschaftler mithilfe einer post hoc-Analyse...

BACKGROUND The aim of this study was to investigate the protective effect of interleukin-6 (IL-6) receptor antagonist tocilizumab (TCZ) on rheumatoid arthritis (RA) and its related mechanism. MATERIAL AND METHODS Thirty RA patients receiving long-term methotrexate therapy at moderate and severe active stages were selected and treated with TCZ 8 mg/kg/time iv gtt intravenously guttae every 4 wee...

Tumour invasion and trophoblastic invasion share the same biochemical mediators: the matrix metalloproteinases (MMP) and their inhibitors. In contrast to tumour invasion of a host tissue, trophoblastic invasion during implantation and placentation is stringently controlled both in tissue localization and developmental stage. The factors responsible for these important regulatory processes are u...

Introduction One of the factors influencing symptoms schizophrenia, which may indicate changes in cognitive functioning patients, is fluctuating level inflammatory cytokines. Objectives The aim review was to analyze available literature on importance selected [interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis α (TNF-α)] schizophrenia and ...