نتایج جستجو برای: interferon β
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BACKGROUND Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-α/β), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leucine-rich repeat (in Flightless I) interacting protein-1 (LRRFIP1) was reported...
Human respiratory syncytial virus (RSV) is a lung tropic virus causing severe airway diseases including bronchiolitis and pneumonia among infants, children, and immuno-compromised individuals. RSV triggers transforming growth factor-β (TGF-β) production from lung epithelial cells and TGF-β facilitates RSV infection of these cells. However, it is still unknown whether RSV infected myeloid cells ...
The IL-1β and type I interferon-β (IFN-β) molecules are important inflammatory cytokines elicited by the eukaryotic host as innate immune responses against invading pathogens and danger signals. Recently, a predominantly nuclear gamma-interferon-inducible protein 16 (IFI16) involved in transcriptional regulation has emerged as an innate DNA sensor which induced IL-1β and IFN-β production throug...
Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been associated with the constitutive production of IFN-β in naive cells. However, the mechanisms capable of modulating constitutive IFN-β expression in the absence of infection r...
BACKGROUND Isolated cases of pulmonary arterial hypertension (PAH) with interferon α or β therapy have been reported, but no population-based estimates of the incidence of the disease after interferon exposure are available. The aim of this study was to determine the incidence of PAH after initiation of interferon therapy, using a large commercial insurance database. METHODS Using National Dr...
Introduction: Interferon (IFN) was first introduced by Isaacs and Linddeman in 1957. It referred to a factor that could cause inhibition in the growth of the live influenza virus. Interferons are intracellular proteins that are involved in many cellular processes such as growth, proliferation, differentiation, metabolism of the extracellular matrix, apoptosis, and regulating immune responses. T...
مقدمه: اینترفرون بتا (ifn-β یا interferon beta) اولین داروی تأیید شده برای درمان مولتیپل اسکلروز (ms یا multiple sclerosis) است. برخی از بیماران مبتلا به ms تحت درمان با ifn-β در برابر این دارو آنتی بادی ایجاد می کنند. آنتی بادی های ضد ifn-β می توانند کارایی بالینی و فعالیت زیستی آن را کاهش دهند. هدف از این مطالعه، طراحی روش elisa برای اندازه گیری آنتی بادی های سرمی ضد اینترفرون در بیماران مبتل...
Microglial activation is a hallmark of human retinal degenerations including Retinitis Pigmentosa and Age-related Macular Degeneration (AMD) [1]. Genetic mouse models have shown that chronic alerted microglia trigger and perpetuate retinal degeneration leading to vision loss [2-3]. Immuno-regulatory microglia exist in the early activation phase but are overwhelmed by rapidly expanding pro-infla...
Background & Aims: Type 1 diabetes is an autoimmune condition associated with the T-cell–mediated destruction of Pancreatic β cells. Vitamin A (retinol) and its metabolites (such as all-trans retinoic acid (ATRA)) have a variety of biological activities including immunomodulatory action in a number of inflammatory and autoimmune conditions. The purpose of this study was to investigate the e...
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