نتایج جستجو برای: inotropic

تعداد نتایج: 5240  

Journal: :Circulation Research 1969

2010
M. Basalus

A 67-years old woman with no cardiac past history was presented postoperatively after elective surgery for pertrochanteric femur fracture with dyspnea, hypotension, pulmonary congestion, oliguria and tachycardia. Cardiogenic shock was suspected and she was transferred to the Coronary Care Unit (CCU) and treated as such with diuretic and an inotropic agent. No improvement occurred and her condit...

Journal: :Journal of Cardiothoracic Surgery 2009
Imdad Ahmed Chad M House William B Nelson

BACKGROUND Left ventricular dysfunction is common after coronary artery bypass graft and valve replacement surgeries and is often treated with inotropic drugs to maintain adequate hemodynamic status. In this study, we aimed to identify the demographic, clinical, laboratory, echocardiographic and hemodynamic factors that are associated with use of inotropic drugs in patients undergoing concomita...

2008
Fabien A. Faucher François E. Gannier Jacques M. Lignon Pierre Cosnay Claire O. Malécot

Faucher FA, Gannier FE, Lignon JM, Cosnay P, Malécot CO. Roles of PKA, PI3K, and cPLA2 in the NO-mediated negative inotropic effect of 2-adrenoceptor agonists in guinea pig right papillary muscles. Am J Physiol Cell Physiol 294: C106–C117, 2008. First published October 17, 2007; doi:10.1152/ajpcell.00231.2007.— Although 2-adrenoceptors represent 15–25% of -adrenoceptors in the guinea pig heart,...

Journal: :The Journal of experimental biology 1999
Versen Gokorsch Fiedler Schipp

Pharmacological examinations of isolated auricles from Sepia officinalis were carried out to analyze the putative role of the monoaminergic transmitter/receptor system in the control of auricle function. In conjunction with histofluorescence studies and HPLC analyses, evidence of a double excitatory serotonergic and noradrenergic innervation of the auricles was obtained. Serotonin-induced posit...

Journal: :Circulation 1992
H Sato M Hori M Kitakaze S Takashima M Inoue A Kitabatake T Kamada

BACKGROUND Adenosine attenuates beta-adrenoceptor-mediated inotropic responses through GTP-binding protein in vitro. The goal of the present study was to test the hypothesis that endogenous adenosine released from the ischemic myocardium blunts the inotropic response to beta-adrenergic stimulation. METHODS AND RESULTS In 45 open-chest dogs, the left anterior descending coronary artery was per...

Journal: :Japanese heart journal 1985
M Kobayashi M Shimotori S Chiba

Both bethanechol and physostigmine produced dose-dependent negative chrono-, dromo- and inotropic effects in the dog isolated atrial preparation. Within a relatively small dose of bethanechol and physostigmine, negative inotropic effect was clearly induced but no significant chrono- and dromotropic changes were observed. With a relatively large dose, the two cholinomimetics caused negative chro...

Journal: :The Yale Journal of Biology and Medicine 1964
S. Evans Downing

The administration of single large doses of angiotensin II has been shown to elicit positive chronotropic and inotropic effects in isolated heart preparations."' Continuous infusions of this hormone in normotensive animals, however, in amounts sufficient to produce marked vasoconstrictor responses, elicit only infrequent and transient increases of contractility.! Occasionally, negative inotropi...

Journal: :Life sciences. Pt. 1: Physiology and pharmacology 1970
M J Antonaccio B R Lucchesi

Michael J. Antonaccio and Benedict R. Lucchesi Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 (Received 22 May 1970 ; in final form 3 August 1970) Glucagon has been shown to be both a positive inotropic and chronotropic agent in many species including man (1-5). However, the positive inotropic effect of glucagon on dog papillary muscles can be r...

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