Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress, inflammation, and aberrant nucleotide biosynthesis. Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e., ITP, dITP, XTP, dXTP, or their mimic: 6-hydroxyaminopurine (HAP) deoxynucleoside triphosphate) and thus regulates nucleotide ...

Adenosine, inosine, and hypoxanthine were isolated from human term placentas by paper chromatography of the diaJyzates of aqueous placental homogenates and quantified by ultraviolet spectroscopy. Placentas obtained upon vaginal delivery contained 230 ± 18 nmoles adenosine/g tissue, 300 ± 29 nmoles inosine/g, and 250 ± 19 nmoles hypoxanthine/g. Three prelabor placentas obtained by cesarean secti...

Adenosine, inosine, and hypoxanthine were isolated from human term placentas by paper chromatography of the diaJyzates of aqueous placental homogenates and quantified by ultraviolet spectroscopy. Placentas obtained upon vaginal delivery contained 230 ± 18 nmoles adenosine/g tissue, 300 ± 29 nmoles inosine/g, and 250 ± 19 nmoles hypoxanthine/g. Three prelabor placentas obtained by cesarean secti...

The present tutorial describes the main features, commands, and proof techniques supported by the Maude ITP 2.0 inductive theorem

We review some techniques of resummation applied to heavy quark production in hadronic scattering and electroproduction near partonic threshold, and discuss the reduction of factorization scale dependence in resummed cross sections.

A procedure has been described for the purification of nucleoside diphosphatase from bovine liver microsomes. The purified enzyme is shown, by analysis in the ultracentrifuge and by polyacrylamide disc gel electrophoresis, to be nearly homogeneous. The enzyme has an s20,u, of 4.9 S. Thiamine pyrophosphatase was purified together with nucleoside diphosphatase. Evidence has been obtained which in...