derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (pdc). the inhibition of transketolase, a thiamine requiring enzyme such as pdf, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (mnpb) is reported here. these studies indicate that the inhibitor binds to the enzyme at the active site. a two-step inhibition was observed, first the in...

background and objectives: alzheimer's disease (ad) is an age dependent disorder. ad is associated with decrease of brain acetylcholine level. nowadays, one of the methods for progression inhibition of ad is using acetylcholinesterase inhibitors. rosaceae is a large plant family. different biological effects of some species of this family have been reported. the aim of the present study was to ...

the management of postprandial hyperglycemia is an important strategy in the control of diabetes mellitus and complications associated with the disease, especially in the diabetes type 2. therefore, inhibitors of carbohydrate hydrolyzing enzymes can be useful in the treatment of diabetes and medicinal plants can offer an attractive strategy for the purpose. vaccinium arctostaphylos leaves are c...

objective: the purpose of the present study was to compare response inhibition and cognitive appraisal in clients with acute stress disorder, clients with posttraumatic stress disorder, and normal individuals . method:  this  was a comparative study. the sample consisted of 40 clients with acute stress disorder, 40 patients with posttraumatic stress disorder, and 40 normal individuals from maza...

background: pteridine metabolic pathway is unusual features of leishmania , which is necessary for the growth of parasite. leishmania has evolved a complex and versatile pteridine salvage network which has the ability of scavenging a wide area of the conjugated and unconjugated pteridines espe-cially folate and biopterin. in this study, we focus on the inhibition of ptr1 gene expression. method...

aim : in this paper effect of combinational usage of calprotectin and etoposide on ags cell line is studied. background : application of combined toxic agents such as etoposide and cicplatin are commonly used for chemotherapy purposes. as a matter of fact, calprotectin and etoposide were both applied on human gastric adenocarcinoma cell line (ags) as antitumor agents. both calprotectin and etop...

objective: the purpose of this study is to compare the executive functions children and adolescents who suffer from attention deficit hyperactivity disorder (adhd) with normal children. method: twenty children with adhd were compared to 19 healthy children terms of some executive functions using the computerized version of tower london, continuous performance test (cpt), and stroop color test. ...

objective: there are controversial reports about factors that affect recovery from stuttering. in the ‎present study, the effect of hand dominancy, fine motor and inhibition control on late ‎recovery from stuttering was investigated among a group of kurdish-persian children who ‎stuttered in iran.‎ method: twenty-two kurdish-persian children aged 7-14 years who stuttered were followed for 6 ‎ye...

polyphenol oxidase (ppo) from tomatoes was extracted and partially purified through  (nh4)2so4 precipitation, dialysis and ion exchange chromatography. the activity of polyphenol oxidase was investigated in solanum lycopersicum. spectrophotometric method was used to assay the enzyme activity and the kinetic constants - maximum enzyme velocity (vmax) and michealis - menten constant (km). of the ...

objective: methanol extract of bran and unpolished grain of two traditional aromatic rice genotypes viz. kalijira and chinigura were assayed for their activity on the growth and initiation of crown-gall tumors on potato disks. materials and methods: three agrobacterium tumefaciens (a. tumefaciens) strain atsl0105, atta0112, and atac0114 were used as the tumor forming agent. collected rice was s...