the aim of this study was to evaluate the effect of organic selenium supplementation on the immune response of broilers vaccinated against coccidiosis, infection bursal disease virus (ibdv) and newcastle diseases virus (ndv). the study included three treatments (t), t1= control (inclusion of inorganic selenium in a basal diet), t2= basal diet + 0.2 ppm of organic selenium as selenomethionine an...

it has been suggested that prf might possibly have an effect on the immune cells. we considered using the intravenous route to apply prf in conditions that are caused by an unresolved immune action or connected to allostatic load, implicating an abnormally reacting immune system to obtain a systemic effect that could possibly be an additional tool in treating some of these conditions. these man...

restraint-induced stress (rs) increases histamine concentration in the brain. there is no previous report regarding the role of histamine receptors in immunomodulatory effect of rs. in the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by rs was evaluated. for this purpose male wistar rats (200-250 g) were immunized with sheep re...

Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...

introduction: hepatitis c virus (hcv) infection is a major public health problem which influences about 170 million people worldwide. different types of vaccines have been designed using hcv structural proteins to control the viral infection. the core nucleocapsid protein is one of the most conserved proteins and a desirable target for hcv vaccines, especially the protein-based vaccines. in cur...

Recent research has added new dimensions to our understanding of classical evolution, according to which evolutionary novelties result from gene mutations inherited from parents to offspring. Language is surely one such novelty. Together with specific changes in our genome and epigenome, we suggest that two other (related) mechanisms may have contributed to the brain rewiring underlying human c...

At its most fundamental, cancer is a genetic disease resulting from inherited or acquired mutations in tumour suppressor genes and proto-oncogenes. Environmental factors, including ingested food components, interact with genetic inheritance to determine individual cancer risk. There is growing evidence that the immune system exerts selective pressure during neoplastic development. Tumour cells ...

Systemic infection caused by Candida species is the fourth leading cause of nosocomial bloodstream infection in modern hospitals and carries high morbidity and mortality despite antifungal therapy. A recent surge of immunological studies in the mouse models of systemic candidiasis and the parallel discovery and phenotypic characterization of inherited genetic disorders in antifungal immune fact...

Autoinflammatory disorders are characterized by spontaneous episodes of systemic inflammation deriving from inherited defects of the innate immune system. Childhood is usually the lifetime involved in most inherited autoinflammatory disorders, but a moderate number of patients may experience disease onset during adulthood. Herein we report our experience in the clinical and genetic approach to ...

Correspondence to: Dr I Ormerod, Department of Neurology, Frenchay Hospital, Bristol, UK; ian.ormerod@ north-bristol.swest.nhs.uk _________________________ I t is not unusual to be asked for a neurological assessment of a patient with some form of immune suppression. Most patients will have an acquired disorder of the immune system and are the focus of this review (table 1). We shall not discus...