Isoxazoline derivatives of the natural products eugenol, 1’- S-acetoxychavicol acetate and sclareol are prepared through 1,3-dipolar cycloaddition reactions in an aqueous buffered system. The compounds evaluated for their antitubercular antibacterial activities. Compounds 2, 2a 3f display strong activity with minimum inhibitory concentration values 26.68, 17.89 14.58 µM, respectively. Furthermo...

wnloaded purpose of this study was to determine the anticancer efficacy of 1,1-bis (3′-indolyl)-1-(p-biphenyl) ne (DIM-C-pPhC6H5) by inhalation delivery alone and in combination with i.v. docetaxel in a murine for lung cancer. An aqueous DIM-C-pPhC6H5 formulation was characterized for its aerodynamic propTumor-bearing athymic nude mice were exposed to nebulized DIM-C-pPhC6H5, docetaxel, or comb...

The worrisome rise in multi and extensively drug-resistant Mycobacterium tuberculosis strains has prompted researchers to look for new, more effective, safer treatments. A variety of N-alkylated indole derivatives were docked against the InhA enzyme achieve this goal. In present study, flexible Ligand docking simulations performed on 88 new compounds protein with PDB ID-4TZK by using Glide modu...

In the article, “Assessment of hepatocellular carcinoma risk based on peg-interferon plus ribavirin treatment experience in this new era of highly effective oral antiviral drugs”, which appeared in Volume 96, Issue 1 ofMedicine, the information about the study funding appeared incorrectly as “This study was supported by an Inha University Hospital grant.” It should have appeared as “This study ...

1 Department of Electrical Engineering, Inha University, 100, Inha-ro, Nam-gu, Incheon 402-751, Korea; [email protected] 2 School of Electrical Engineering, Kookmin University, Jeongneung-ro, Seongbuk-gu, Seoul 136-702, Korea; [email protected] (S.-H.K.); [email protected] (I.-Y.C.) 3 Department of Electrical Engineering, Myongji University, 116, Myongji-ro, Cheoin-gu, Yongin-si, Gyeonggi-d...

InhA, the NADH-dependent enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis (Mtb) is the proposed main target of the first-line antituberculosis drug isoniazid (INH). INH activity is dependent on activation by the catalase peroxidase KatG, a Mtb enzyme whose mutations are linked to clinical resistance to INH. Other inhibitors of InhA that do not require any preliminary activat...

The growth process of Bacillus thuringiensis Bt4.0718 strain was studied using proteomic technologies. The proteins of Bt whole cells at three phases-middle vegetative, early sporulation, and late sporulation-were extracted with lysis buffer, followed with separation by 2-DE and identified by MALDI-TOF/TOF MS. Bioactive factors such as insecticidal crystal proteins (ICPs) including Cry1Ac(3), C...

An examination of the pattern of lipid biosynthetic responses to isoniazid (INH) treatment of Mycobacterium tuberculosis and Mycobacterium smegmatis suggests that the mode of action of activated INH differs between these 2 organisms. Transformation of M. smegmatis with inhA on a plasmid construct conferred high-level resistance to INH, while the same construct failed to confer resistance upon M...

Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we cond...