Growing evidence suggests that plant secondary compounds (PSCs) ingested by mammals become more toxic at elevated ambient temperatures, a phenomenon known as temperature-dependent toxicity. We investigated temperature-dependent toxicity in the desert woodrat (Neotoma lepida), a herbivorous rodent that naturally encounters PSCs in creosote bush (Larrea tridentata), which is a major component of ...

Abstract: Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting clinical trial investigation in adult healthy human subjects. Extrapolation of between various rodent non-rodent animal species critical biomedical researchers during initial drug development. The objective this review to provide practical ...

Background: The same conversion factors (k-factors) of Single CT (SECT) are applied to estimate the Effective Dose (ED) in Dual Energy Computed Tomography (DECT). However, k-factors for different organs need independently validating DECT, due conditions DECT. Objective: This study aimed calculate organ dose and imaging protocols (liver, chest, cardiac, abdomen) male female phantoms. Material Me...

The aim of the study was to investigate sonographically the effect of Gongronema latifolium on gastric emptying of semi-solid meals in diabetic dogs. Twenty-five alloxan-induced diabetic dogs were randomly allotted into five groups of five dogs each in a randomised placebo-controlled study. These are placebo, prokinetic dose, low dose, moderate dose and high dose groups. The placebo group serve...

Background: This study aimed to investigate dose area product (DAP), effective dose, and radiation risk in newborn infants hospitalized in neonatal intensive care units in Isfahan and Kashan. Materials and Methods: During a period of six months, DAP for chest X-ray examinations for newborn infants hospitalized in NICUs of five special hospitals including Beheshti (in Kashan), Al-Zahra, Imam Hos...

BACKGROUND Long-term exposure to ingested arsenic has been documented to induce peripheral vascular disease, ischemic heart disease, and cerebral infarction in a dose-response relationship. This study further examined the biological gradient between ingested inorganic arsenic and carotid atherosclerosis. METHODS AND RESULTS We studied 199 male and 264 female adult residents from the southwest...