helicobacter pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. inflammatory aspects may prompt the production of radical oxygen substance (ros) which may damage cells and release 8-hydroxydyoxyguanosine (8-ohdg) to serum. in this study, we evaluate the prevalence of h. pyl...

Acute inflammation, an integral part of host defence and immunity, is a highly conserved cellular response to pathogens and other harmful stimuli. An inflammatory stimulation triggers transcriptional activation of selective pro-inflammatory genes that carry out specific functions such as anti-microbial activity or tissue healing. Based on the nature of inflammatory stimuli, an extensive exploit...

neurological inflammatory diseases are developing rapidly. different factors involved in the pathogenesis of these diseases. in this article, we discuss some of the mechanisms are dealt with. an aberrant procedure of beta-amyloid precursor protein (bapp) to form neurotoxic beta-amyloid peptides and an accumulated insoluble polymer of beta –amyloid (ba) that forms the senile plaque. the above pr...

results like other cancers, prostate cancer is caused by an accumulation of genetic alterations in a cell that drives it to malignant growth. specific genes and gene alterations have been suggested to play a role in its development and progression. aneuploidy, loss of heterozygosity, gene mutations, hypermethylation and inactivation of specific tumour suppressor genes such as gstpi, apc, mdr1, ...

Although predominantly associated with health benefits, the gut microbiota has also been shown to harbor genes that promote inflammation. In this work, we report a method for the direct detection and quantification of these pro-inflammatory bacterial genes by PCR and qPCR in DNA extracted from human stool samples. PCR reactions were performed to detect (i) the pks island genes, (ii) tcpC, which...

vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. interleukin 17 (il-17a) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (cox2). the aim of this study was to investigate the gene expression of il-17 and cox2 in peripheral blood leukocy...