Editor—It is extremely difficult to evaluate the effects of pharmacological treatment pain in newborn infants. This because major challenges measurement and relief these vulnerable patients, continuously changing pharmacokinetics (PK) pharmacodynamics (PD) drugs currently used clinical practice treat neonatal pain.1Van den Anker J. Reed M. Allegaert K. Kearns G. Developmental changes pharmacody...

Objective This study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. Methods This study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those having a singleton SGA neonate born between 29 and 34 complete gestational weeks. The neonates born ...

Hyperbilirubinemia is a common problem during neonatal period especially in preterm neonates. Transcutaneous bilirubin measurement (TcB) by special devices had been documented as an effective tool for predicting neonatal jaundice in full term neonate, but for preterm infants the present evidences are controversial. We carried out a prospective study in Shariati Hospital NICU. 126 paired TcB/tot...

objective: asphyxia  is  a  major  cause  of  acute  mortality  and  chronic  neurologic  disability  in  neonates. we sought to  define  the  predictive  values  of  serum  concentrations  of  interleukin-1β  in  newborns  with perinatal asphyxia to see if there is a relation between interleukin-1β (il-1β) levels to the short term neurological deficit.  methods: this was a prospective (case-co...

Candidal meningitis is a serious complication of systemic candidiasis and cause of major morbidity and mortality. This is especially true in very low birth weight premature infants. We describe a premature neonate who suffered from systemic candidal infection with brain parenchymal involvement detected by cranial ultrasound. This patient survived after antifungal treatment but delayed neurodeve...

Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother's...

Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother’s...

Objective. Touch is one of the first strong positive senses that develop in neonate. Therapeutic touch could be considered as a complementary treatment in Neonate intensive care units (NICU). Methods. This quasi-experimental study was conducted to compare the effect of Yakson and GHT on behavioral reaction of preterm infants hospitalized in NICU in south-east of Iran. 90 preterm infants partici...