نتایج جستجو برای: inducible nitric oxide synthase inos

تعداد نتایج: 275550  

2009
Dana F. Flavin

Abstract The rapid reversal of splenomegaly in Epstein Barr Virus EBV infected children and young adults was seen in over 50 patients treated with a combination therapy that reduced reactive oxygen species, increased interferon gamma and decreased free nitric oxide in lymphocytes. The patients showed dramatic improvement within 24 hours with successful remission of the disease and complete reve...

Journal: :Current Botany 2021

Herbs are essential resources for drug discovery. However, numerous challenges stand in front of the scientific community to discover novel drugs from herbs. To explore validation behind precious knowledge traditional medicine, we focused on achieving virtual screening detect potential medicines Five bioactive compounds known anti-inflammatory medicinal plants were examined through molecular do...

2015
Yasuko Iwakiri

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, ...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2002
Norihito Suzuki Atsuhiro Sakamoto Ryo Ogawa

Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) plays a role in the pathophysiology of septic shock. The depression of cardiac contractility in such situations is mediated by proinflammatory cytokines, including interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha). The effects of two NOS inhibitors with different isoform selectivity were compared in isol...

2012
Ehab M. M. Ali Soha M. Hamdy Tarek M. Mohamed

Nitric oxide has been found to play an important role as a signal molecule in many parts of the organism as well as a cytotocic effector molecule of nonspecific immune response. Nitric oxide is very important functions both in helminthes and mammalian hosts. Nitric oxide may react with proteins and nucleic acids. In addition to binding to heme groups, e.g. of guanylate cyclase, hemoglobin, and ...

Journal: :The European respiratory journal 2000
N H ten Hacken D S Postma G Drok M Smith J Kraan W Timens

Nitric oxide production by endothelial cells may have important consequences for the development of airway inflammation as well as for airway obstruction. The present study investigated whether the expression of vascular inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in human bronchi differs between asthmatic and healthy subjects, and whether it shows a circ...

Introduction: In stroke models, Inducible Nitric Oxide Synthase (iNOS) expression initiates cellular toxicity due to excessive Nitric Oxide (NO) generation. Anchusa italica is a medicinal herb with anti-inflammatory, antioxidant and neuroprotective properties. This study evaluated the antioxidant activity and NOS mRNA expression of the Hydroalcoholic Extract Of Anchusa Italica (HEAI) in an expe...

2012
Estefania Lopez-Arenas Alan Mackay-Sim Juan Bacigalupo Lorena Sulz

Neurogenesis continues in the adult brain and in the adult olfactory epithelium. The cytokine, leukaemia inhibitory factor and nitric oxide are both known to stimulate neuronal progenitor cell proliferation in the olfactory epithelium after injury. Our aim here was to determine whether these observations are independent, specifically, whether leukaemia inhibitory factor triggers neural precurso...

Journal: :iranian journal of basic medical sciences 0
seyyedeh elaheh mousavi department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran department of toxicology–pharmacology, faculty of pharmacy, pharmaceutical science branch, islamic azad university (iaups), tehran, iran seyed mahdi rezayat department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran department of toxicology–pharmacology, faculty of pharmacy, pharmaceutical science branch, islamic azad university (iaups), tehran, iran maliheh nobakht department of anatomy, school of medicine, iran university of medical sciences, tehran, iran seyed soheil saeedi saravi department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran

objective(s): an increase in nitric oxide (no) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. since minocycline has been shown to inhibit no overproduction, we aimed to examine its role in a rat model of ccl4-induced cirrhotic cardiovascular complications. materials and methods: portal pressure and inotropic responsiveness of isolated papillary muscles to iso...

Journal: :Endocrinology 2006
Ebru Karpuzoglu Jillian B Fenaux Rebecca A Phillips Andrea J Lengi François Elvinger S Ansar Ahmed

Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues by estrogen. We now show that activation of splenocytes with T cell stimulants ...

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