Cyclizine (1-benzhydryl-4-methyl-piperazine, CAS 82-92-8, CYC, I), a piperazine derivative, belongs to H1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other H1-receptor antagonists. In this study, two new tolyl and cumene derivatives of I (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

This study investigates the effect of sub-phonemic variation in bilabial stop and sibilant fricative consonants on word identification. Recent research suggests that sub-phonemic variation in stop voicing contrasts influences lexical processing. The present study seeks further support for this view by examining listeners’ responses to synthetic speech varying along VOT and fricative place conti...

Hyperprolactinemia can be a complication of conventional neurolepics as well as risperidone. We report the third case of attenuation of risperidone-induced hyperprolactinemia by aripiprazole.

A novel propargylic electrophile-induced tandem intermolecular addition-semipinacol rearrangement was developed efficiently under mild conditions. Various allylic silylether substrates as well as Co-complexed propargylic species were applicable to this protocol and gave a series of synthetically useful β-propargyl spirocyclic ketones in moderate to good yields. Its synthetic application was als...

Reversal of symptomatic antipsychotic-induced hyperprolactinemia with addition of aripiprazole Paraskevi Kotorki, Parthena Pelka, Christina Leotsakou, Aikaterini Kalogeropoulou, Markella Fiste, Georgios Vagionis, Anastasia Roussi, Periklis Paterakis From 1 International Congress on Neurobiology and Clinical Psychopharmacology and European Psychiatric Association Conference on Treatment Guidance...

Within this paper we study the Minkowski sum of prisms (" Cephoids ") in a finite dimensional vector space. For a vector a ∈ R n with positive components we write ¯ a = (1 ¯ a 1 1 ¯ an) and denote by = ¯ a = {x ∈ R n || ¯ a, x 1 , x 0} the associated prism. We provide a representation of a finite sum of prisms in terms of inequalities.

Let SH denote the homothety class generated by a convex set S ⊂ R: SH = {a + λS | a ∈ R, λ > 0}. We determine conditions for the Minkowski sum BH + CH or the Minkowski difference BH ∼ CH of homothety classes BH and CH generated by closed convex sets B,C ⊂ R to lie in a homothety class generated by a closed convex set (more generally, in the union of countably many homothety classes generated by...

Fakhruddin has proved that for two lattice polygons P and Q any lattice point in their Minkowski sum can be written as a sum of a lattice point in P and one in Q, provided P is smooth and the normal fan of P is a subdivision of the normal fan of Q. We give a shorter combinatorial proof of this fact that does not need the smoothness assumption on P .

Under the extra assumption that the boundary is of class C this was proven by S. Nakajima (= A. Matsumura) in 1926 Theorem 1 solves this problem. For convex bodies with C boundaries and positive curvature Nakajima’s result was generalized by Chakerian [?] in 1967 to “relative geometry” where the width and brightness are measured with with respect to some convex body K0 symmetric about the origi...