The discovery and development of novel anthelmintic classes is essential to sustain the control of socioeconomically important parasitic worms of humans and animals. With the aim of offering novel, lead-like scaffolds for drug discovery, Compounds Australia released the 'Open Scaffolds' collection containing 33,999 compounds, with extensive information available on the physicochemical propertie...

AIM To evaluate the effect of metoclopramide on gastric emptying in coronary artery bypass graft (CABG) surgery patients with early enteral nutrition and to evaluate the effect of metoclopramide on motility of the gallbladder in these patients. METHODS A prospective, randomized, placebo-controlled, double-blind study of 40 patients treated at cardiosurgical intensive care unit after CABG surg...

The objective of this study was to evaluate the quality of thawed semen of Holstein bull by computer assisted sperm analysis (CASA). A total sample of 40 straws imported from USA (total bulls = 4; 5 ejaculates per bull; 2 straws per ejaculate) was analysed by CASA using an IVOS. Semen motility was evaluated for kinetics parameters after thawing. The percentage of total mobile spermatozoa (%TMOB...

OBJECTIVE To evaluate cryodamage on human sperm motility, cryosurvival rate, and sperm chromatin assessed by acridine orange staining method (AO test) after a six-month freeze-thawing process using liquid nitrogen vapor. STUDY DESIGN Experimental study. MATERIAL AND METHOD Twenty normal semen samples were obtained from the male partner of infertile couples attending the infertility unit, Si...

Milk samples were collected from quarters of 35 cows with subclinical mastitis (California mastitis test [CMT] positive and somatic cell counts [SCC] >500,000 cells/ml in individual quarter foremilk), as well as from 37 healthy controls. Compared to the levels observed in milk from healthy quarters, milk from quarters with subclinical mastitis showed elevated sodium (91.97 vs 52.93 mg/dl), chlo...

background: high level of semen reactive oxygen species is considered as an important factor in male infertility. sesame has antioxidant properties, which could be effective on improvement of semen parameters. this study was designed to determine the effects of sesame on sperm quality.   materials and methods: twenty‑five infertile men entered this clinical trial. they were treated with a 3â€...

OBJECTIVE The aim of the present study was to evaluate three thawing rates on the post thaw motility, viability and chromatin structure of buffalo semen frozen in 0.5-ml straws. MATERIALS AND METHODS In this experimental study semen was collected with artificial vagina (42℃) from four buffalo bulls.Split pooled ejaculates (n=4) were extended at 37℃ with a Bioxcell® extender. Semen was cooled ...

reactive oxygen species (ros)plays an important role in sperm motility. the physiological generation at low concentration induces beneficial effects on sperm functions and plays a significant role in sperm metabolism. meanwhile, the excessive generation of reactive oxygen species can overwhelm protective mechanism and triggers changes in lipid and protein layers of sperm plasma membrane, which ...

Motility could be an important adaptation of heterotrophic bacteria and archaea, and it may have ecological and biogeochemical implications. However, the limited observations so far show that only a small fraction (≤10%) of bacteria is motile. We report a systematic 10 mo long field study off the coast of La Jolla, California, as well as a mesocosm study to examine bacterial motility and its re...