In the title compound, C(30)H(25)NO(5)S, all the five-membered rings are in envelope conformations with the spiro and methylene C atoms as the flap atoms. Intra-molecular C-H⋯O inter-actions stabilize the mol-ecular structure and form S(6) and S(7) ring motifs. The mean plane through the hexa-hydro-pyrrolo-[1,2-c]thia-zole ring [r.m.s deviation of 0.0393 (1) Å] makes dihedral angles of 60.92 (5...

In the title compound, C(16)H(11)BrO, the dihydro-indene ring system is approximately planar, with a maximum deviation of 0.008 (2) Å. The mean plane of this ring system forms a dihedral angle of 3.73 (11)°, with the bromo-substituted benzene ring. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into sheets parallel to the ab plane and further stabilization is prov...

The five-membed ring of the title compound, C(11)H(13)NO, that is fused with the aromatic ring is approximately planar (r.m.s. deviation = 0.037 Å) despite the presence of the sp(3)-hybrid-ized ethyl-ene linkage. The hy-droxy group of the N-bound hy-droxy-ethyl chain serves as hydrogen-bond donor to the azomethine N atom of an adjacent mol-ecule, generating a hydrogen-bonded C(2)-symmetric dimer.

The indan skeleton is present in a variety of molecules with important biological activity, including the wellknown Indinavir and Aricept. Our research group has investigated approaches to obtain indans from 1,2dihydronaphthalenes, using a thallium(III)-promoted ring contraction reaction. During these studies, we found that a side chain at the double bond has a strong influence in the reaction ...

The title compound, C(14)H(13)BrN(2)O, was obtained by reaction of indan-1-yl methane-sulfonate with 2-amino-5-bromo-pyridin-3-ol in the presence of caesium carbonate. The indane ring system is approximately planar [all but one of the C atoms are coplanar within 0.03 Å, the latter atom being displaced by 0.206 (2) Å from the mean plane through the remaining atoms] and forms a dihedral angle of ...

In the title mol-ecule, C(17)H(11)F(3)O, the indan ring system and the trifluoro-methyl-substituted benzene ring are approximately individually planar and form a dihedral angle of 1.81 (5)° with each other. In the crystal, mol-ecules are linked by pairs of weak bifurcated (C-H)(2)⋯O hydrogen bonds to form centrosymmetric dimers, generating R(2) (1)(6) and R(2) (2)(10) ring motifs. These dimers ...

In the title compound, C(16)H(11)ClO, the dihedral angle between the almost planar dihydro-indene ring system (r.m.s. deviation = 0.009 Å) and the chloro-benzene ring is 3.51 (14)°. In the crystal, mol-ecules are connected by C-H⋯O and weak C-H⋯Cl inter-actions, forming infinite layers parallel to (101).

In the title compound, C(18)H(16)O(3), the mean plane of the nine-membered indane system makes a dihedral angle of 3.71 (17)° with the benzene ring of the dimethoxy-phenyl group. The mol-ecular conformation is stabilized by intra-molecular C-H⋯O hydrogen contacts. The crystal structure is stabilized by inter-molecular C-H⋯O inter-actions, which link neighbouring mol-ecules into one-dimensional ...

Kinetics of the reactions of four benzenesulfonyl-stabilized carbanions (1a-d)- with reference electrophiles (quinone methides 2 and diarylcarbenium ions 3) have been determined in dimethyl sulfoxide solution at 20 degrees C in order to derive the reactivity parameters N and s according to the linear free-energy relationship logk(20 degrees C) = s(N + E) (eqn (1)). The additions of (1a-d)- to o...