Introduction: Inappropriate administration of antimicrobials has led to increased antibiotic resistance as well as burden of infectious diseases. Antibiotic stewardship programs (ASPs) help prevent resistance through improved utilization of antimicrobial agents while potentially decrease costs of treatment. Method: We reviewed 186 infectious disease (ID) consultations from two internal disea...

the objective of this study was to determine the frequency of microorganisms isolated from blood samples of patients admitted to intensive care unit (icu), and the rate of their resistance to common administered antibiotics in an iranian icu. one-hundred patients with systemic inflammatory response syndromes (sirs), hospitalized in icu of sina hospital, tehran, iran, were entered to this cross-...

background and objectives: the emergence of extended-spectrum β-lactamase (esbl)-producing shigella spp.  is of increasing clinical concern specially in children worldwide. the aim of this study was to investigate the occurrence of extended-spectrum β-lactamase producing shigella spp. in tehran, iran. materials and methods: the study included all shigella isolates recovered from pediatric patie...

conclusions periodic evaluation of antimicrobial susceptibility for c. perfringens should be performed. harboring of enterotoxigenic c. perfringens in individuals not necessarily results in diarrhea. results of 136 stool samples including diarrhea [48] and non-diarrhea [88] ones, 83 (61.02%) c. perfringens were cultured. of these 83, 79 c. perfringens isolates showed the alpha-toxin (phospholip...

conclusions: ten percent of the isolates were positive for meca gene among the vancomycin-oxacillin resistant strains, while van gene was not detected in any of the isolates. the data obtained would be useful in clinical control of resistant staphylococcal strains. results: a total of 120 staphylococcus isolates were screened, out of which, 32 (26%) were susceptible to both methicillin and vanc...

background: human exposure to antibiotic resistant bacteria (arb) is a public health concern which could occur in a number of ways. wastewaters seem to play an important role in the dissemination of bacteria and antibiotic resistant genes (args) in our environment. the aim of this study was to evaluate the occurrence of three groups of arb and their resistance genes in hospital and municipal wa...

Objective and Background The aim of this study was so assess the knowledge and attitude of the people in Iran regarding the antibacterial resistance caused by antibiotics. Introduction increasing concern toward antibiotic resistance led to many researches on the causes of this issue. The public awareness plays a critical role, according to the studies. Another important factor...

Coagulase-negative staphylococci (CoNS) isolated in neonatal late-onset sepsis are often antibiotic resistant. We analyzed CoNS from skin and feces of neonates during hospitalization. Antibiotic resistance of skin isolates increased during hospitalization, especially in Staphylococcus haemolyticus. Staphylococcus warneri showed low antibiotic resistance. Our data suggest that different CoNS spe...

Biofilms are considered to be highly resistant to antimicrobial agents. Several mechanisms have been proposed to explain this high resistance of biofilms, including restricted penetration of antimicrobial agents into biofilms, slow growth owing to nutrient limitation, expression of genes involved in the general stress response, and emergence of a biofilm-specific phenotype. However, since combi...

The use of phages for treating bacterial pathogens has recently been advocated as an alternative to antibiotic therapy. Here, we test a hypothesis that bacteria treated with phages may show more limited evolution of antibiotic resistance as the fitness costs of resistance to phages may add to those of antibiotic resistance, further reducing the growth performance of antibiotic-resistant bacteri...