The purpose of the present study was to evaluate the enhancement of tolbutamide (TBM) oral bioavailability and hypoglycaemic activity through complexation with beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). TBM and its freeze-dried inclusion complexes were administered to rabbits (New zealand breed; n=6), in a dose of 20 mg/kg. TMB plasma levels were measured by H...

The aim of present work was to enhance the aqueous solubility and dissolution rate of the curcumin, a water insoluble yellow colored phenolic pigment with good anti-inflammatory property obtained from dried rhizomes of plant Cucrcuma longa. This paper presents physicochemical evaluations of curcumin and its molecular inclusion complexes with α-cyclodextrin. Phase solubility studies revealed lin...

The structural elucidation of 2α-cyclodextrin/1-octanethiol, 2α-cyclodextrin/1-octylamine and 2α-cyclodextrin/1-nonanoic acid inclusion complexes by nuclear magnetic resonance (NMR) spectroscopy and molecular modeling has been achieved. The detailed spatial configurations are proposed for the three inclusion complexes based on 2D NMR method. ROESY experiments confirm the inclusion of guest mole...

This paper describes the evaluation of the stability of amylose-polymer inclusion complexes under solution state in dimethyl sulfoxide (DMSO) depending on guest polymers. The three complexes were prepared by the vine-twining polymerization method using polytetrahydrofuran (PTHF), poly(ε-caprolactone) (PCL), and poly(l-lactide) (PLLA) as guest polymers. The stability investigation was conducted ...

We show that a set of gates that consists of all one-bit quantum gates (U(2)) and the two-bit exclusive-or gate (that maps Boolean values (x, y) to (x, x⊕y)) is universal in the sense that all unitary operations on arbitrarily many bits n (U(2n)) can be expressed as compositions of these gates. We investigate the number of the above gates required to implement other gates, such as generalized D...

new hetero-binuclear hg-cu schiff base complexes were prepared by reaction of 2,2'-[1,1'-(2,2-‎dimethylpropane-1,3-diyldinitrilo)-diethyldyne]diphenolato}copper(ii) (cul1) and 6,6'-x-2,2'-[(2,2-‎dimethylpropane-1,3-diyl)bis(nitrilomethanylylidene)]diphenolato copper(ii) [(x = ethoxy (cul2) and ‎methoxy (cul3)], with hgcl2 to give [cu(l1)hgcl2] (1), [cu(l2)hgcl2] (2), and [cu...