The integration of the International Classification of Diseases for Oncology (ICD-O) and the NCI Thesaurus (NCIT) is expected to facilitate the integration of epidemiology data (cancer registries) with basic and clinical research data. We evaluated the degree to which ICD-O and NCIT provide consistent representations of neoplasms. 1,550 concepts (515 for topography and 1,035 for morphology) are...

Models are needed that describe how topography and other watershed characteristics affect the chemical composition of runoff waters, yet little spatially distributed data exist to develop such models. A topographically driven flushing mechanism for nitrate (NO3 ) and dissolved organic carbon has been described in recent literature; however, this mechanism has not yet been thoroughly tested. A 2...

a r t i c l e i n f o a b s t r a c t The elevation of an orogenic belt is commonly related to crustal/lithosphere thickening. Here, we discuss the Apennines as an example to show that topography at a plate margin may be controlled not only by isostatic adjustment but also by dynamic, mantle-driven processes. Using recent structural constraints for the crust and mantle we find that the expected...

This paper presents the complete development and experimental validation of a microsystem designed to systematically assess the impact of surface topography on cell adhesion and dynamics. The microsystem includes two pools for culturing cells and for including chemicals. These pools are connected by several channels that have different microtextures, along which the cells crawl from one well to...

Introduction: The Olympus Mons shield volcano on the northwestern edge of Mars’ Tharsis rise is the largest volcano in the solar system. Its volcanic history is intimately tied with the volcanic and geodynamic history of Tharsis and of Mars as a whole. Previous studies used crater counting to estimate the age of the flanks of Olympus, with typical values of ~200 Myr [1]. However, establishing t...