Introduction: This study is to formulate the Euterpe Oleracea in-situ gel for better treatment of conjunctivitis. The ophthalmic drug solution can treat ocular infections effectively. Aim: Formulation and evaluation Eutepe conjunctivitis Methodology: containing prepared by using different polymers like carbopol-940, HPMC K15, K100, K4M, as a pH triggered gelling system, these are used controlle...

The oral delivery of drugs having narrow absorption window in the gastro-intestinal tract is limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the time of absorption. To provide controlled delivery of drugs novel drug delivery systems have been developed. Different systems have been developed to increase the gastric residen...

Polymeric hydrogel is a promising class of drug delivery systems with the controlled release behavior in the body. In-situ forming hydrogels can be injected into the body as a fluid which forms a gel within the body tissue and improve the efficacy of the drugs. Various polymers have been used as in-situ hydrogel formulations. These polymeric formulations can form gels at body temperature while ...

BACKGROUND Molecules taken up by olfactory and trigeminal nerve neurons directly access the brain by the nose-to-brain pathway. In situ-forming mucoadhesive gels would increase the residence time of intranasal material, favoring the nose-to-brain delivery. In this first approach, brain radioactivity after intranasal administration of (32)P-small interference RNA (siRNA) complexed with poly(amid...

Objective: To develop in-situ gel formulations of Lornoxicam for sustained release to reduce the dosing frequency in treatment rheumatoid arthritis. Methods: The method ion-sensitive formation was used this study. situ were prepared by varying concentrations sodium alginate as a bio-degradable gel-forming polymer, CaCl2 cross-linking agent, and chitosan, HPMCK4, HPMCK15, guar gum, gellan xantha...

The authors evaluated and compared the efficacies of eye drops and in situ forming gel of pefloxacin mesylate in pseudomonas induced conjunctivitis in 40 rabbits. The in-situ forming gel of pefloxacin mesylate was formulated as a liquid and when administered in the cul-de-sac, it gets converted to gel. The objective of the present research work was to demonstrate the in vivo activity of in situ...

Various nanoparticles have been investigated as novel drug delivery systems, including solid lipid nanoparticles (SLNs). Due to their rapid clearance from systemic circulation, nanoparticles do not provide sustained action in most cases. Different strategies have been employed to overcome this problem. In this direction, the present study introduces erodible in-situ forming gel systems as poten...