Cell fate determination and differentiation are central processes in the development of multicellular organisms, and the Arabidopsis (Arabidopsis thaliana) root epidermis provides a model system to study the molecular basis of these processes. A lateral inhibition mechanism mediated by an R3 single-repeat MYB protein, CAPRICE (CPC), has been proposed to explain the specification of the two type...

Aurora B kinase (AURKB) is the catalytic subunit of the chromosomal passenger complex (CPC), an essential regulator of chromosome segregation. In mitosis, the CPC is required to regulate kinetochore microtubule (K-MT) attachments, the spindle assembly checkpoint, and cytokinesis. Germ cells express an AURKB homolog, AURKC, which can also function in the CPC. Separation of AURKB and AURKC functi...

CAPRICE (CPC), a small, R3-type Myb-like protein, is a positive regulator of root hair development in Arabidopsis. Cell-to-cell movement of CPC is important for the differentiation of epidermal cells into trichoblasts (root hair cells). CPC is transported from atrichoblasts (hairless cells), where it is expressed, to trichoblasts, and generally accumulates in their nuclei. Using truncated versi...

(CPC-CBT) The main article contains a general description of CPC-CBT. This information supplements what could be included in the printed issue of Volume 95. Research Support Dr. Melissa Runyon and her colleague, Dr. Esther Deblinger, developed CPC-CBT through a series of research studies. An initial pilot study was conducted to address the feasibility of a 16-week CBT group approach that incorp...

The development of Arabidopsis thaliana epidermal cells includes the differentiation of trichomes and root hairs. The TRANSPARENT TESTA GLABRA 1 (TTG1) gene encodes a WD40 protein that induces trichome differentiation and reduces root hair formation in Arabidopsis. The CAPRICE (CPC) gene family includes CPC, ENHANCER OF TRY AND CPC1 (ETC1), ENHANCER OF TRY AND CPC2 (ETC2), and CPC LIKE MYB3 (CP...

During cytokinesis, the chromosomal passenger complex (CPC) promotes midzone organization, specifies the cleavage plane, and regulates furrow contractility. The localizations of the CPC are coupled to its cytokinetic functions. At the metaphase-to-anaphase transition, the CPC dissociates from centromeres and localizes to midzone microtubules and the equatorial cortex. CPC relocalization to the ...

The chromosomal passenger complex (CPC) localizes to centromeres where it activates the mitotic checkpoint in response to inappropriate inter-kinetochore tension. This error correction function is essential for proper chromosome segregation. Here we define several critical features of CPC localization and function. First, the Borealin dimerization domain suppresses dynamic exchange at the centr...

APPLIED RESEARCH Completed studies Studies on sputum transported in cetyl pyridinium chloride for detection of M. tuberculosis Background Drug resistance surveys require transportation of sputum samples collected from pulmonary TB patients in cetyl pyridinium chloride (CPC) solution to the reference laboratory for bacteriological investigations. It was observed that smears from sputum transport...

Calcium phosphate cements (CPCs) are successfully used as bone substitutes in dentistry and orthopaedic applications. This study investigated the physico-chemical-mechanical properties of and in vitro biological properties (cell response) of CPCs prepared with amorphous calcium carbonate phosphate (ACCP) doped with magnesium (ACCP-Mg), zinc (ACCp-Zn) or fluoride (ACCP-F) ions. The experimental ...

A neutral mononuclear Fe(II) complex with spin crossover (SCO) properties, Fe2(SCN)2 (1) (L = 2-(2-(trifluoromethyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline), was solvothermally synthesized. It displays a new example of two-step SCO with Tc1↓ = 250 K, Tc1↑ = 260 K and Tc2 = 295 K.