Inflammatory myofibroblastic tumor (IMT) is an uncommon benign tumor of intermediate neoplastic potential, characterised by spindle cell proliferation with characteristic fibroinflammatory and pseudosarcomatous appearance. A subset of IMT with histologic atypia and/or clinical aggressiveness is also known. IMTs occur in the mesentery, omentum, retroperitoneum, pelvis, and abdominal soft tissues...

The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study subjects, 104 patients experienced hypoglycemic episodes. Increases in the me...

BACKGROUND Endothelial progenitor cells (EPCs) are involved in the endothelium repair. Low circulating EPC levels are predictive of cardiovascular events in HIV-negative subjects. The impact of HIV infection on EPCs, and the role of EPCs in HIV-associated cardiovascular disease, is not known. We hypothesized that circulating EPCs would be inversely associated with carotid artery intima-media th...

BACKGROUND AND PURPOSE Carotid intima-media thickness (IMT) is a surrogate marker of subclinical atherosclerosis and a strong predictor of stroke and myocardial infarction. The object of this study was to determine the association between carotid IMT and 702 single nucleotide polymorphisms in 145 genes. METHODS B-mode carotid ultrasound was performed among 408 Hispanics from the Northern Manh...

Inflammatory myofibroblastic tumor (IMT) of the genitourinary tract is a wellknown entity. The majority of the literature characterizes IMT of the bladder as a benign, slow growing tumor in children. We present two cases of aggressive IMT. Although rhabdomyosarcoma is more common, IMT should remain within the differential diagnosis for any bladder mass found in a child or young adult. The diagn...

BACKGROUND AND PURPOSE Elevated urinary albumin excretion (UAE) is associated with an increased carotid intima-media thickness (IMT). Because angiotensin-converting enzyme inhibitors as well as statins have been shown to lower UAE and the progression of IMT, we assessed the effects of fosinopril and pravastatin on carotid IMT in subjects with an increased UAE (15 to 300 mg/24 h). METHODS IMT ...

PURPOSE We have shown that individuals with recurrent nonspecific low back pain (LBP) and healthy individuals breathing against an inspiratory load decrease their reliance on back proprioceptive signals in upright standing. Because individuals with LBP show greater susceptibility to diaphragm fatigue, it is reasonable to hypothesize that LBP, diaphragm dysfunction, and proprioceptive use may be...

Background—Increased carotid artery intima-media thickness (IMT) and elevated C-reactive protein (CRP) are both associated with the occurrence of stroke. We investigated whether elevated CRP is a risk factor for ischemic stroke independent of carotid IMT and studied the interaction between CRP and IMT. Methods and Results—We studied 5417 participants aged 65 years or older without preexisting s...

Background—Increased carotid intimal-medial thickness (IMT) and coronary artery calcification (CAC) are used as 2 markers of early atherosclerosis. Our objectives were to assess whether increased IMT and CAC are related and to determine the relationship between cardiovascular risk factors and carotid IMT in young adults. Methods and Results—A sample of 182 men and 136 women aged 33 to 42 years ...

Skin, being the largest organ of the body, is an important site for drug administration. However, most of the drugs have poor permeability and thus drug delivery through the skin is very challenging. In this study, we examined the transdermal delivery capability of IMT-P8, a novel cell-penetrating peptide. We generated IMT-P8-GFP and IMT-P8-KLA fusion constructs and evaluated their internalizat...