The aim of the present study was to produce glycosylation variants of the therapeutic Lewis Y-specific humanized IgG1 antibody IGN311 to enhance cell-killing effector function. This was achieved via genetic engineering of the glycosylation machinery of the antibody-producing host. Antibody genes were transiently cotransfected with acetyl-glycosaminyltransferase-III genes into human embryonic ki...

We provide an improved compared to [5]–[7] local convergence analysis and complexity for the interpolatory Newton method for solving equations in a Banach space setting. The results are obtained using more precise error bounds than before [5]–[7] and the same hypotheses/computational cost. RESUMEN Nosotros entregamos aqúı un análisis de convergencia local y complejidad para el método de interpo...

The effect of removal of resultant gas resulted in enhancement of the H2 yield. The technique of CO2 scavenging resulted in H2 yield being improved from 408 mL g(-1) to reach the maximum of 422 mL g'. The highest hydrogen productivity of 87.9 ml L(-1) h(-1) was obtained by CO2 scavenging. Biomass concentration was enhanced to 1.47 g L(-1), Y(P,X) of 287 ml g(-1) L(-1), Y(X/S) of 0.294 and Y(H2/...

Let (X, dX) be an n-point metric space. We show that there exists a distribution D over non-contractive embeddings into trees f : X → T such that for every x ∈ X, ED [ max y∈X\{x} dT ( f (x), f (y)) dX(x, y) ] ≤ C(log n), where C is a universal constant. Conversely we show that the above quadratic dependence on log n cannot be improved in general. Such embeddings, which we call maximum gradient...

Y(3)Al(5)O(12):Ce phosphors have been prepared and used as an effective scattering layer on top of a transparent layer of nanocrystalline TiO(2) for dye sensitized solar cells (DSSCs). The Y(3)Al(5)O(12):Ce scattering layer increases the photocurrent of DSSCs due to the enhanced light harvesting mainly via the improved light absorption and scattering. Under one sun illumination (AM 1.5G, 100 mW...

We report a case of reactive arthritis (ReA) triggered by Yersinia enterocolitica enteritis. A 24-year-old Japanese man developed polyarthritis in the lower limbs. Two weeks prior to these symptoms, he noted diarrhea, right lower abdominal pain and a fever. Y. enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high an...

The probability that a transient Markov chain, or a Brownian path, will ever visit a given set Λ, is classically estimated using the capacity of Λ with respect to the Green kernel G(x, y). We show that replacing the Green kernel by the Martin kernel G(x, y)/G(0, y) yields improved estimates, which are exact up to a factor of 2. These estimates are applied to random walks on lattices, and also t...

Excitation functions were measured by the stacked-foil technique for Sr(p, xn)Y reactions from threshold up to 25 MeV. From the measured cross sections integral yields of Y, Y and Y were calculated. The optimum energy range for the production of Y is Ep = 14 → 9 MeV; the Y yield amounts to 1.75 MBq (47.3μCi/μA·h) and the Y and Y impurities to 2.0 and 4.4%, respectively. The isomeric cross secti...

B1(dsFv)-PE33 is a recombinant immunotoxin composed of a mutant form of Pseudomonas exotoxin (PE) that does not need proteolytic activation and a disulfide-stabilized Fv fragment of the anti-Lewis(y) monoclonal antibody B1, which recognizes a carbohydrate epitope on human carcinoma cells. In this molecule, amino acids 1-279 of PE are deleted and domain Ib (amino acids 365-394) is replaced by th...

Single ventricle heart defects are among the most serious congenital heart diseases, and are uniformly fatal if left untreated. Typically, a three-staged surgical course, consisting of the Norwood, Glenn, and Fontan surgeries is performed, after which the superior vena cava (SVC) and inferior vena cava (IVC) are directly connected to the pulmonary arteries (PA). In an attempt to improve hemodyn...