Lupus nephritis (LN) affects up to 50% of patients with Systemic Lupus Erythematosus (SLE) and is associated with a worse prognosis. LN usually develops within the first 5 years of the onset of the disease. We report three patients with very delayed LN (DLN) diagnosed after 15 or more years after SLE diagnosis. The three patients were non-Caucasian women with adolescent or adult-onset SLE. Each...

The anti-inflammatory effect of adenosine was previously found to be mediated via activation of the A3 adenosine receptor (A3AR). The aim of the present study was to decipher the molecular mechanism involved with the inhibitory effect of IB-MECA, an A3AR agonist, on adjuvant-induced arthritis. The adjuvant-induced arthritis rats responded to IB-MECA treatment with a decrease in the clinical sco...

Background Blockade of the PD-1 pathway is a therapeutic strategy to reinvigorate T cell responses against tumors, and when combined with other biologic therapies in first line setting this achieves significant clinical response about 25% hepatocellular carcinoma (HCC) patients. We hypothesize that phenotypic diversity tumor infiltrating cells can explain, at least partially, disparate immunoth...

Abstract Active immune suppression can mediate the balance between protective cellular immunity and harmful immunopathology. This occur locally, at an infection site, or in regional draining lymph nodes (dLN). Immune regulation is of particular importance sites such as lung where aberrant immunopathology result loss tissue function. We have recently identified a novel population CD11b+CD103+CCR...

Abstract The 2018 exceptional drought over the Colorado Plateau motivated unprecedented responses by individuals and organizations. Some of these made clear that proactive adaptive measures were fundamental to resilience. Climate service organizations (CSOs) supporting observing realized utility a network share document successful responses. In February 2020, small group CSOs resource managers ...

Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity remains unexplored. Here, we demonstrate that VEGF-C promotes immune tolerance in murine melanoma. In B16 F10 melanomas expressing a foreign a...

Direct administration of dendritic cells (DCs) genetically modified to express secondary lymphoid tissue chemokine (SLC) into growing B16 melanoma could result in a substantial, sustained influx of T cells within the mass with only a transient increase in T-cell numbers in the draining lymph node (DLN). DCs were retained at the tumor site with only a very small percentage trafficking to the DLN...

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that expr...