The aim of this study was to assess the toxic effects of zearalenone (ZEA) on the immune function. Ovariectomised rats were treated daily by gavage with 3.0 mg/kg of ZEA for 28 days. Body weight gain, food consumption, haemotological parameters, lymphoid organs, and their cellularities were evaluated. Moreover, acquired immune responses and macrophage activity were also assessed. ZEA promoted r...

Topical microbicides are intended for frequent use by women in reproductive age. Hence, it is essential to evaluate their impact on mucosal immune function in the vagina. In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide. Its effect on the vaginal immune function was determined by localizing Toll-like rec...

The study was undertaken to evaluate immunotoxic effecls of eypermethrin administered orally (in ground nut oil) to male albino rats at dose levels (mglkg) of 0 (control). 5. 10. 20 and 40 once daily for 90 days. Cypermethrin administration produced a significant leucopenia at 40 mglkg on day 90. A dose dependent decrease (P > 0.05) in delayed type hypersensitvity reaction was noticed on day 61...

the contamination of cereals with toxic secondary metabolites of fungi, mycotoxins, is a permanent challenge in human health. these toxins are produced by a few fungi are mainly of the genera fusarium , aspergillus and penicillium . ochratoxin a is a nephrotoxic mycotoxin, which possesses carcinogenic, teratogenic, immunotoxic and possibly neurotoxic properties. zearalenone is a non-steroidal e...

Recognition that xenobiotics can impair the function of the immune system has led to progress in immunotoxicology over the last two decades. Exposure to immunotoxic chemicals in the environment, however, may be expected to result in more subtle forms of immunosuppression that may be difficult to detect, leading to increased incidences of infections such as influenza and common cold. Studies on ...

A crucial period for the development of the immune system occurs in utero. This results in a high fetal vulnerability to immunotoxic exposure, and indeed, immunotoxic effects have been reported, demonstrating negative effects on immune-related health outcomes and immune functionality. Within the NewGeneris cohort BraMat, a subcohort of the Norwegian Mother and Child Cohort Study (MoBa), immunot...

Beryllium (Be2+) is an important industrial metal because of its unusual material properties: it lighter than aluminium and six times stronger steel. a strategic due to low density combined with strength, neutron absorption, high melting point modulus elasticity. often alloyed other metals such as copper component materials used in the aerospace, automotive, energy, defense, medical, electronic...

Trichloroethylene (TCE) has been associated with a variety of immunotoxic effects and may be associated with an increased risk of non-Hodgkin lymphoma (NHL). Altered serum immunoglobulin (Ig) levels have been reported in NHL patients and in animals exposed to TCE. Recently, we reported that occupational exposure to TCE is associated with immunosuppressive effects and immune dysfunction, includi...