نتایج جستجو برای: immunopathology

تعداد نتایج: 2299  

Journal: :Journal of immunology 2008
William Stohl Noam Jacob William J Quinn Michael P Cancro Huaxin Gao Chaim Putterman Xiaoni Gao Luminita Pricop Michael N Koss

In otherwise non-autoimmune-prone C57BL/6 (B6) mice rendered genetically deficient in CD152 (CTLA-4), polyclonal hypergammaglobulinemia with increased levels of systemic lupus erythematosus (SLE)-associated IgG autoantibodies, glomerular IgG and C3 deposition, and interstitial nephritis all developed by 3-5 wk of age. Remarkably, superimposing genetic deficiency of BAFF (B cell-activating facto...

2016
Yashaswini Kannan Jimena Perez-Lloret Yanda Li Lewis J Entwistle Hania Khoury Stamatia Papoutsopoulou Radma Mahmood Nuha R Mansour Stanley Ching-Cheng Huang Edward J Pearce Luiz Pedro S de Carvalho Steven C Ley Mark S Wilson

Persistent TH2 cytokine responses following chronic helminth infections can often lead to the development of tissue pathology and fibrotic scarring. Despite a good understanding of the cellular mechanisms involved in fibrogenesis, there are very few therapeutic options available, highlighting a significant medical need and gap in our understanding of the molecular mechanisms of TH2-mediated imm...

2013
Markus Cornberg Laurie L. Kenney Alex T. Chen Stephen N. Waggoner Sung-Kwon Kim Hans P. Dienes Raymond M. Welsh Liisa K. Selin

The balance between protective immunity and immunopathology often determines the fate of the virus-infected host. How rapidly virus is cleared is a function of initial viral load, viral replication rate, and efficiency of the immune response. Here, we demonstrate, with three different inocula of lymphocytic choriomeningitis virus (LCMV), how the race between virus replication and T cell respons...

2016
Mary Raule Fulvia Cerruti Paolo Cascio

proteasomes among the species examined, although some interesting species-specific features were observed.

Journal: :The Journal of clinical investigation 2011
Paul Elkington Takayuki Shiomi Ronan Breen Robert K Nuttall Cesar Augusto Ugarte-Gil Naomi F Walker Luísa Saraiva Bernadette Pedersen Francesco Mauri Marc Lipman Dylan R Edwards Brian D Robertson Jeanine D'Armiento Jon S Friedland

Mycobacterium tuberculosis can cause lung tissue damage to spread, but the mechanisms driving this immunopathology are poorly understood. The breakdown of lung matrix involves MMPs, which have a unique ability to degrade fibrillar collagens at neutral pH. To determine whether MMPs play a role in the immunopathology of tuberculosis (TB), we profiled MMPs and their inhibitors, the tissue inhibito...

2000
Dennis J. O'Callaghan Patrick M. Smith Yunfei Zhang Warren D. Grafton PATRICK M. SMITH YUNFEI ZHANG WARREN D. GRAFTON STEPHEN R. JENNINGS

2017
Elizabeth J. Glass Rebecca Baxter Richard J. Leach Oliver C. Jann

Farm animals remain at risk of endemic, exotic and newly emerging viruses. Vaccination is often promoted as the best possible solution, and yet for many pathogens, either there are no appropriate vaccines or those that are available are far from ideal. A complementary approach to disease control may be to identify genes and chromosomal regions that underlie genetic variation in disease resistan...

1997
Irun R. Cohen

cytokines, and then the phenomenon is resurrected unThis paper presents some questions and issues reder a different name. garding the concept of the Th1/Th2 dichotomy and Parenthetically, the phenomenon of the ‘‘T suppressummarizes results using an hsp60 peptide to treat the sor cell’’ has been unusually resistant to its molecular spontaneous autoimmune process of diabetes in NOD resurrection. ...

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