Immunity is responsible for the defense mechanism of the body but in case of autoimmune diseases, its role gets diverted. Like so many other diseases, asthma is also considered as one of the most common autoimmune diseases to be occurring in community. Asthma is defined as a chronic inflammatory airway disease that is characterized by airway hyper reactivity and mucus hypersecretion that result...

although the majority of the patients with traumatic brain injury presents with injuries involving the extremities, there was a clear paucity of adequate experimental polytrauma models. to close this gap, we conducted several studies to establish two different polytrauma mice models including both closed and open traumatic brain injury. male c57bl mices with a mean weight of 23g were anesthetiz...

Immunological mechanisms play the leading role in pathogenesis of inflammatory destructive processes periodontium. That's why clinical manifestations chronic generalized periodontitis depend not so much on pathogenicity and virulence corresponding microflora but character bacterial-gostal interrelations, that is, many respects - degree macroorganism reactivity, which is determined by functional...

In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatric diseases, where study subjects are almost exclusively children, blood volumes available for immunological studies are limited and as such mu...

We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that imm...

The mesenteric lymph nodes in total colectomy specimens from patients with ulcerative colitis or Crohn's colitis were assessed for immunological reactivity. Despite the suggestion of previous work using different methods that immunological difference between the diseases exist and may be important in pathogenesis, no significant differences were found in this study. Changes were observed in bot...