background and objectives: biological scaffold resources composed of extracellular matrix (ecm) have been shown to make easy the practical remodeling of various tissues in both animal and human studies. the goal of current study was to make sheet form of ecm from sheep’s urinary bladder. methods: ecm was extracted from sheep’s urinary bladder according to standard method. scanning electron mic...

Urinary bladder voiding is a complex mechanism depending upon interplay among detrusor, urothelium, sensory and motor neurons and connective tissue cells. The identity of some of the latter cells is still controversial. We presently attempted to clarify their phenotype(s) in the human urinary bladder by transmission electron microscopy (TEM) and immunohistochemistry. At this latter aim, we used...

  Background and Objectives: Biological scaffold resources composed of extracellular matrix (ECM) have been shown to make easy the practical remodeling of various tissues in both animal and human studies. The goal of current study was to make sheet form of ECM from sheep’s urinary bladder. Methods: ECM was extracted from Sheep’s urinary bladder according to standard method. Scanning electron ...

These studies examined the expression of cyclooxygenase-2 (COX-2) expression in the urothelium and suburothelial space and detrusor from rats treated with cyclophosphamide (CYP) to induce acute (4 h), intermediate (48 h), or chronic (10-day) cystitis. Western blot analysis and immunohistochemistry were used to demonstrate COX-2 expression. In whole mount preparations of urinary bladder, nerve f...

small cell carcinoma of the urinary bladder (sccub) is an extremely rare bladder malignancy characterized by an aggressive clinical behavior. so, it is important to diagnose this high grade disease by urinary cytology. we report a case of sccub in an old man with chronic lymphocytic leukemia (cll) in remission, while bladder tumor was diagnosed by cytology. with this article, we aimed to review...

Urothelium-specific overexpression of nerve growth factor (NGF) in the urinary bladder of transgenic mice stimulates neuronal sprouting in the urinary bladder, produces increased voiding frequency, and results in increased referred somatic hypersensitivity. Additional NGF-mediated pleiotropic changes might contribute to the increased voiding frequency and pelvic hypersensitivity observed in the...

The expression of acid-sensing ion channel (ASIC) isoforms, ASIC1, ASIC2a, and ASIC3, was examined in the urinary bladder after cyclophosphamide (CYP)-induced cystitis of varying duration (4 h, 48 h, and chronic). Immunohistochemical, Western blot, and quantitative PCR approaches were used to evaluate channel expression and effects of CYP-induced cystitis in whole urinary bladder and split-blad...

One of the rarest tumors involving the urinary bladder is the pheochromocytoma. A case of pheochromocytoma of the urinary bladder in a young female suffering from headache and cystitis for many years is reported. Twenty-four hour urine VMA was normal. The patient was never hypertensive except during surgical manipulation of the tumor. Biopsy of the bladder resulted in massive hemorrhage.

one of the rarest tumors involving the urinary bladder is the pheochromocytoma. a case of pheochromocytoma of the urinary bladder in a young female suffering from headache and cystitis for many years is reported. twenty-four hour urine vma was normal. the patient was never hypertensive except during surgical manipulation of the tumor. biopsy of the bladder resulted in massive hemorrhage.

background: differentiation between the muscularis mucosae (mm) and muscularispropria (mp) of the bladder remains challenging. objective: to identify mm- and mp-specific antigens that could be of potential value for staging of urothelialcarcinomain a pilot study. method: the expression of 12 protein antigens in 11 human bladder specimens was examined. there were 5 post radical cystectomy specim...